2353496-84-9

2353496-84-9 structure

Name: Thalidomide-C2-amido-C2-COOH
Chemical Name: Thalidomide-C2-amido-C2-COOH
CAS Number: 2353496-84-9
Molecular Formula: C₁₉H₂₀N₄O₇
Molecular Weight: 416.38
Catalog: Signaling Pathways PROTAC E3 Ligase Ligand-Linker Conjugate
Create Date: 2020-01-23 22:57:51
Modify Date: 2024-01-12 21:20:47
Thalidomide-C2-amido-C2-COOH incorporates a CRBN ligand for the E3 ubiquitin ligase, and a linker. Thalidomide-C2-amido-C2-COOH can be used to design PROTAC CDK2/9 Degrader-1 (HY-130709)[1].

Name	Thalidomide-C2-amido-C2-COOH

Description	Thalidomide-C2-amido-C2-COOH incorporates a CRBN ligand for the E3 ubiquitin ligase, and a linker. Thalidomide-C2-amido-C2-COOH can be used to design PROTAC CDK2/9 Degrader-1 (HY-130709)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> E3 Ligase Ligand-Linker Conjugate
Target	Cereblon
References	[1]. Zhou F, et al. Development of selective mono or dual PROTAC degrader probe of CDK isoforms. Eur J Med Chem. 2019 Dec 6;187:111952.

Molecular Formula	C₁₉H₂₀N₄O₇
Molecular Weight	416.38

Hazard Codes	Xi