2245697-84-9

2245697-84-9 structure

Name: Thalidomide-O-amido-PEG3-C2-NH2 hydrochloride
Chemical Name: Thalidomide-O-amido-PEG3-C2-NH2 hydrochloride
CAS Number: 2245697-84-9
Molecular Formula: C₂₃H₃₁ClN₄O₉
Molecular Weight: 542.97
Catalog: Signaling Pathways PROTAC E3 Ligase Ligand-Linker Conjugate
Create Date: 2020-06-01 10:51:02
Modify Date: 2024-04-04 12:11:52
Thalidomide-O-amido-PEG3-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology[1].

Name	Thalidomide-O-amido-PEG3-C2-NH2 hydrochloride
Synonyms	MFCD31656717

Description	Thalidomide-O-amido-PEG3-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> E3 Ligase Ligand-Linker Conjugate
Target	Cereblon
In Vitro	Thalidomide-O-amido-PEG3-C2-NH2 hydrochloride is composed of Degron (E3 ubiquitin ligase) and a linker, and they are used in PROTAC technology. Thalidomide-O-amido-PEG3-C2-NH2 binds to the targeting ligand to induce the target protein (including BRD4, BRD2, and BRD3) degradation[1].
References	[1]. Methods to induce targeted protein degradation through bifunctional molecules. WO2017007612A1.