1217616-61-9

1217616-61-9 structure
1217616-61-9 structure
  • Name: TSHR antagonist S37
  • Chemical Name: TSHR antagonist S37
  • CAS Number: 1217616-61-9
  • Molecular Formula: C25H20N2O3S2
  • Molecular Weight: 460.57
  • Catalog: Signaling Pathways GPCR/G Protein TSH Receptor
  • Create Date: 2020-01-24 08:12:51
  • Modify Date: 2024-01-07 11:14:54
  • TSHR antagonist S37 is a selective and competitive thyrotropin receptor (TSHR) antagonist. TSHR antagonist S37 is the racemate of TSHR antagonist S37a[1].

Name TSHR antagonist S37
Description TSHR antagonist S37 is a selective and competitive thyrotropin receptor (TSHR) antagonist. TSHR antagonist S37 is the racemate of TSHR antagonist S37a[1].
Related Catalog
Target

TSHR[1]

In Vitro TSHR antagonist S37 reduces also cAMP activation induced by the small molecule agonist C2[1]. TSHR antagonist S37 (10-100 µM) does not affect cell viability in the concentration range for the Hek293T-TSHR cell line[1].
References

[1]. Marcinkowski P, et al. A New Highly Thyrotropin Receptor-Selective Small-Molecule Antagonist with Potential for the Treatment of Graves' Orbitopathy. Thyroid. 2019 Jan;29(1):111-123.

Molecular Formula C25H20N2O3S2
Molecular Weight 460.57