1144161-05-6

1144161-05-6 structure

Name: A3AR antagonist 2
Chemical Name: N-[2-(4-Methoxyphenyl)-1-oxo-1,2-dihydropyrido[2,3-e][1,2,4]triaz olo[4,3-a]pyrazin-4-yl]benzamide
CAS Number: 1144161-05-6
Molecular Formula: C₂₂H₁₆N₆O₃
Molecular Weight: 412.40100
Catalog: Signaling Pathways GPCR/G Protein Adenosine Receptor
Create Date: 2017-08-13 09:02:07
Modify Date: 2024-04-01 16:31:29
A3AR antagonist 2 (compound 18) is a potent Human A3 adenosine receptor antagonist with an Ki value of 4.54 nM[1].

Name	N-[2-(4-Methoxyphenyl)-1-oxo-1,2-dihydropyrido[2,3-e][1,2,4]triaz olo[4,3-a]pyrazin-4-yl]benzamide

Description	A3AR antagonist 2 (compound 18) is a potent Human A3 adenosine receptor antagonist with an Ki value of 4.54 nM[1].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor
Target	hA3:4.54 nM (Ki)
References	[1]. Pyrido[2,3-e]-1,2,4-triazolo[4,3-a]pyrazin-1-one as a New Scaffold To Develop Potent and Selective Human A3 Adenosine Receptor Antagonists. Synthesis, Pharmacological Evaluation, and Ligand?Receptor Modeling StudiesJ. Med. Chem., 2009, 52 (8), pp 2407-2419 [2]. Vittoria Colotta, et al. Pyrido[2,3-e]-1,2,4-triazolo[4,3-a]pyrazin-1-one as a New Scaffold To Develop Potent and Selective Human A3 Adenosine Receptor Antagonists. Synthesis, Pharmacological Evaluation, and Ligand−Receptor Modeling Studies. J. Med. Chem. 2009, 52, 8, 2407-2419.

Molecular Formula	C₂₂H₁₆N₆O₃
Molecular Weight	412.40100
Exact Mass	412.12800
PSA	106.90000
LogP	3.07330

1144160-95-1

98-88-4

~88%

1144161-05-6

Literature: Colotta, Vittoria; Lenzi, Ombretta; Catarzi, Daniela; Varano, Flavia; Filacchioni, Guido; Martini, Claudia; Trincavelli, Letizia; Ciampi, Osele; Pugliese, Anna Maria; Traini, Chiara; Pedata, Felicita; Morizzo, Erika; Moro, Stefano Journal of Medicinal Chemistry, 2009 , vol. 52, # 8 p. 2407 - 2419

Precursor 2
1144160-95-1 98-88-4
DownStream 0

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