2180923-05-9

2180923-05-9 structure

Name: Bcl-2/Bcl-xl inhibitor 1
Chemical Name: Bcl-2/Bcl-xl inhibitor 1
CAS Number: 2180923-05-9
Molecular Formula: C₄₅H₄₈ClN₇O₈S
Molecular Weight: 882.42
Catalog: Signaling Pathways Apoptosis Bcl-2 Family
Create Date: 2020-04-07 19:36:25
Modify Date: 2024-01-06 22:22:32
Bcl-2/Bcl-xl inhibitor 1 (compound 6) is a dual Bcl-2 and Bcl-xl inhibitor with anti-tumor activity, extracted from patent WO2018027097A1. Bcl-2/Bcl-xl inhibitor 1 exhibits IC50 values of 2 nM and 5.9 nM for Bcl-2 and Bcl-xl, respectively[1].

Name	Bcl-2/Bcl-xl inhibitor 1

Description	Bcl-2/Bcl-xl inhibitor 1 (compound 6) is a dual Bcl-2 and Bcl-xl inhibitor with anti-tumor activity, extracted from patent WO2018027097A1. Bcl-2/Bcl-xl inhibitor 1 exhibits IC50 values of 2 nM and 5.9 nM for Bcl-2 and Bcl-xl, respectively[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Bcl-2 Family Research Areas >> Cancer
Target	Bcl-2:2 nM (IC50) Bcl-xL:5.9 nM (IC50)
In Vitro	Bcl-2/Bcl-xl inhibitor 1 (compound 6) exhibits IC50 values of 5.5 nM and 6.4 nM in Bcl-2 dependent RS4;11 cells and Bcl-xl dependent Molm13 cells[1].
References	[1]. WANG, Chia, et al. N-(PHENYLSULFONYL)BENZAMIDES AND RELATED COMPOUNDS AS BCL-2 INHIBITORS. Patent. WO2018027097A1.