Name | DHODH-IN-13 |
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Description | DHODH-IN-13 (Compound 7a) is a hydroxyfurazan analog of A771726. DHODH-IN-13 is a dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 4.3 μM for rat liver DHODH. DHODH-IN-13 can be used for rheumatoid arthritis[1]. |
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Related Catalog | |
Target |
IC50: 4.3 μM for (Rat liver DHODH)[1] |
In Vitro | DHODH-IN-13 (Compound 7a) is a hydroxyfurazan analog of A771726 and is stable under physiological conditions. When DHODH-IN-13 is docked in silico at the DHODH active site, a BQN-like pose is obtained with the deprotonated furazan hydroxyl facing Arg136 instead of Tyr356, thus effectively mimicking the carboxyl group of BQN and related compounds[1]. |
References |
Molecular Formula | C10H6F3N3O3 |
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Molecular Weight | 273.17 |