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1364791-86-5

1364791-86-5 structure
1364791-86-5 structure
  • Name: DHODH-IN-13
  • Chemical Name: DHODH-IN-13
  • CAS Number: 1364791-86-5
  • Molecular Formula: C10H6F3N3O3
  • Molecular Weight: 273.17
  • Catalog: Signaling Pathways Cell Cycle/DNA Damage DNA/RNA Synthesis
  • Create Date: 2020-04-09 08:51:31
  • Modify Date: 2024-01-10 19:19:24
  • DHODH-IN-13 (Compound 7a) is a hydroxyfurazan analog of A771726. DHODH-IN-13 is a dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 4.3 μM for rat liver DHODH. DHODH-IN-13 can be used for rheumatoid arthritis[1].

Name DHODH-IN-13
Description DHODH-IN-13 (Compound 7a) is a hydroxyfurazan analog of A771726. DHODH-IN-13 is a dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 4.3 μM for rat liver DHODH. DHODH-IN-13 can be used for rheumatoid arthritis[1].
Related Catalog
Target

IC50: 4.3 μM for (Rat liver DHODH)[1]

In Vitro DHODH-IN-13 (Compound 7a) is a hydroxyfurazan analog of A771726 and is stable under physiological conditions. When DHODH-IN-13 is docked in silico at the DHODH active site, a BQN-like pose is obtained with the deprotonated furazan hydroxyl facing Arg136 instead of Tyr356, thus effectively mimicking the carboxyl group of BQN and related compounds[1].
References

[1]. Lolli ML, et al. New inhibitors of dihydroorotate dehydrogenase (DHODH) based on the 4-hydroxy-1,2,5-oxadiazol-3-yl (hydroxyfurazanyl) scaffold. Eur J Med Chem. 2012 Mar;49:102-9.

Molecular Formula C10H6F3N3O3
Molecular Weight 273.17