1643958-89-7
1643958-89-7 structure
- Name: PDK1-IN-RS2
- Chemical Name: PDK1-IN-RS2
- CAS Number: 1643958-89-7
- Molecular Formula: C15H9ClN2O2S3
- Molecular Weight: 380.89
- Catalog: Signaling Pathways PI3K/Akt/mTOR PDK-1
- Create Date: 2020-04-11 14:34:18
- Modify Date: 2024-01-15 11:22:33
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PDK1-IN-RS2 is a mimic of peptide docking motif (PIFtide) and is a substrate-selective PDK1 inhibitor with a Kd of 9 μM. PDK1-IN-RS2 suppresses the activation of the downstream kinases S6K1 by PDK1[1].
| Name | PDK1-IN-RS2 |
|---|
| Description | PDK1-IN-RS2 is a mimic of peptide docking motif (PIFtide) and is a substrate-selective PDK1 inhibitor with a Kd of 9 μM. PDK1-IN-RS2 suppresses the activation of the downstream kinases S6K1 by PDK1[1]. |
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| Related Catalog | |
| Target |
Kd: 9 μM (PDK1)[1] |
| In Vitro | PDK1-IN-RS2 stimulates the catalytic activity of PDK1 toward a peptide substrate by sixfold. The sulfonyl group of PDK1-IN-RS2 interacts with Arg131 through a salt bridge, because the sulfonamide is likely ionized under the crystallization conditions[1]. |
| References |
| Molecular Formula | C15H9ClN2O2S3 |
|---|---|
| Molecular Weight | 380.89 |