1161883-51-7

1161883-51-7 structure

Name: Propargyl-PEG5-CH2CO2-NHS
Chemical Name: Propargyl-PEG4-O-C1-NHS ester
CAS Number: 1161883-51-7
Molecular Formula: C₁₇H₂₅NO₉
Molecular Weight: 387.38
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2020-04-23 16:28:26
Modify Date: 2024-01-12 10:17:19
Propargyl-PEG4-O-C1-NHS ester (compound 8) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

Name	Propargyl-PEG4-O-C1-NHS ester

Description	Propargyl-PEG4-O-C1-NHS ester (compound 8) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs Alkyl/ether
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
References	[1]. Kussrow A, et al. Measurement of monovalent and polyvalent carbohydrate-lectin binding by back-scatteringinterferometry. Anal Chem. 2009 Jun 15;81(12):4889-97.