1589522-46-2
1589522-46-2 structure
- Name: Propargyl-PEG5-amine
- Chemical Name: Propargyl-PEG5-amine
- CAS Number: 1589522-46-2
- Molecular Formula: C13H25NO5
- Molecular Weight: 275.341
- Catalog: Signaling Pathways Antibody-drug Conjugate ADC Linker
- Create Date: 2018-07-05 01:46:21
- Modify Date: 2024-01-10 13:50:11
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Propargyl-PEG5-amine is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG5-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].
| Name | Propargyl-PEG5-amine |
|---|---|
| Synonyms | PROPARGYL-PEG5-NH2 |
| Description | Propargyl-PEG5-amine is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG5-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. |
|---|---|
| Related Catalog | |
| Target |
PEGs Non-cleavable |
| In Vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. |
| References |
[1]. Robert Zamboni, et al. Raf-degrading conjugate compounds. WO2018200981A1. |
| Density | 1.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 360.4±37.0 °C at 760 mmHg |
| Molecular Formula | C13H25NO5 |
| Molecular Weight | 275.341 |
| Flash Point | 166.5±20.2 °C |
| Exact Mass | 275.173279 |
| LogP | -1.54 |
| Vapour Pressure | 0.0±0.8 mmHg at 25°C |
| Index of Refraction | 1.464 |