Shanghai Nianxing Industrial Co., Ltd
China
Product Name: D-Cl-amidine
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Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang

1404060-15-6

1404060-15-6 structure

1404060-15-6 structure

Name: D-Cl-amidine
Chemical Name: D-Cl-amidine
CAS Number: 1404060-15-6
Molecular Formula: C₁₄H₁₉ClN₄O₂
Molecular Weight: 310.78
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2020-06-01 10:48:23
Modify Date: 2024-01-05 09:08:06
D-Cl-amidine is a potent and highly selective PAD1 inhibitor. D-Cl-amidine is well-torelated with no significant toxicity[1].

Name	D-Cl-amidine

Description	D-Cl-amidine is a potent and highly selective PAD1 inhibitor. D-Cl-amidine is well-torelated with no significant toxicity[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Epigenetics >> Protein Arginine Deiminase
In Vitro	D-Cl-amidine (200-400 μM) is effective in significantly decreasing cell viability in MDA-MB-231 cells[1]. D-Cl-amidine increase caspase 3 activity, indicating that inhibition of PAD1 leads to an increase in apoptosis[1].
In Vivo	D-Cl-amidine, administered by iv at a dose of 2.5 mg/kg, is still detected after 2 h in serum at a concentration of ~21 nM and at 4 h at ~10 nM. D-Cl-amidine is still observed in the blood serum at a concentration of ∼10 nM at 4 h when administered by ip at a dose of 10 mg/kg[1].
References	[1]. Bicker KL, et al. D-amino acid based protein arginine deiminase inhibitors: Synthesis, pharmacokinetics, and in cellulo efficacy. ACS Med Chem Lett. 2012 Oct 26;3(12):1081-1085.

Molecular Formula	C₁₄H₁₉ClN₄O₂
Molecular Weight	310.78