1016456-76-0

1016456-76-0 structure

Name: EZ-482
Chemical Name: EZ-482
CAS Number: 1016456-76-0
Molecular Formula: C₂₃H₁₉ClN₄O₅S
Molecular Weight: 498.94
Catalog: Research Areas Neurological Disease
Create Date: 2020-06-01 18:50:28
Modify Date: 2024-02-06 19:11:07
EZ-482, a novel ligand of apolipoprotein (apoE), binds to sites on apoE in the C-terminal domain with Kds of 5-10 μM for apoE3 and apoE4. EZ-482 binds to apoE4 by a unique N-terminal allosteric effect. EZ482 has the potential for Alzheimer’s diseas[1].

Name	EZ-482

Description	EZ-482, a novel ligand of apolipoprotein (apoE), binds to sites on apoE in the C-terminal domain with Kds of 5-10 μM for apoE3 and apoE4. EZ-482 binds to apoE4 by a unique N-terminal allosteric effect. EZ482 has the potential for Alzheimer’s diseas[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
Target	Kd: 5-10 μM (apoE3 and apoE4)[1]
In Vitro	EZ-482 binds to sites on apoE in the C-terminal domain encompassing residues 229-243 and 258-265[1]. EZ-482 (0.5, 1, 5, 10 μM; 1 hour) blocks heparin binding in a concentration-dependent manner[1].
References	[1]. Tridib Mondal, et al. ApoE: In Vitro Studies of a Small Molecule Effector. Biochemistry. 2016 May 10;55(18):2613-21.

Molecular Formula	C₂₃H₁₉ClN₄O₅S
Molecular Weight	498.94