2095432-39-4
2095432-39-4 structure
- Name: MRT67307 hydrochloride
- Chemical Name: MRT67307 hydrochloride
- CAS Number: 2095432-39-4
- Molecular Formula: C26H37ClN6O2
- Molecular Weight: 501.06
- Catalog: Signaling Pathways Autophagy Autophagy
- Create Date: 2020-06-01 14:24:00
- Modify Date: 2024-01-24 12:48:23
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MRT67307 hydrochloride is a dual inhibitor of the IKKε and TBK-1 with IC50s of 160 and 19 nM, respectively[1]. MRT67307 hydrochloride also inhibits ULK1 and ULK2 with IC50s of 45 and 38 nM, respectively. MRT67307 hydrochloride also blocks autophagy in cells[2].
| Name | MRT67307 hydrochloride |
|---|
| Description | MRT67307 hydrochloride is a dual inhibitor of the IKKε and TBK-1 with IC50s of 160 and 19 nM, respectively[1]. MRT67307 hydrochloride also inhibits ULK1 and ULK2 with IC50s of 45 and 38 nM, respectively. MRT67307 hydrochloride also blocks autophagy in cells[2]. |
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| Related Catalog | |
| Target |
TBK1:19 nM (IC50, at 0.1 mM ATP) IKKε:160 nM (IC50, at 0.1 mM ATP) ULK2:38 nM (IC50) ULK1:45 nM (IC50) Autophagy |
| In Vitro | MRT67307 inhibits IKKϵ and TBK1 with IC50 values of 160 and 19 nM when assayed at 0.1 mM ATP in vitro, but did not inhibit IKKα or IKKβ even at 10 μM[1]. MRT67307 (2 μM) prevents the phosphorylation of IRF3 in bone-marrow-derived macrophages (BMDMs). MRT67307 (2 μM) dose not suppresse the activation of JNK or p38 MAPK by poly(I:C)[1]. MRT67307 (1 nM-10 μM) prevents the production of IFNβ in macrophages[1]. MRT67307 (10 μM) is sufficient to reduce phospho-ATG13 to control levels[2]. MRT67307 (10 μM) blocks autophagy in mouse embryonic fibroblasts (MEFs)[2]. MRT67307 (5 µM; 4 h) abrogates TBK1/IKKε-induced CYLD phosphorylation in 293T cells[3]. Western Blot Analysis[3] Cell Line: 293T cells Concentration: 5 µM Incubation Time: 4 hours Result: Abrogated TBK1/IKKε-induced CYLD phosphorylation. |
| References |
| Molecular Formula | C26H37ClN6O2 |
|---|---|
| Molecular Weight | 501.06 |