2101200-10-4

2101200-10-4 structure

Name: PROTAC BRD4-binding moiety 1
Chemical Name: PROTAC BRD4-binding moiety 1
CAS Number: 2101200-10-4
Molecular Formula: C₂₃H₂₁N₃O₂
Molecular Weight: 371.43
Catalog: Signaling Pathways Epigenetics Epigenetic Reader Domain
Create Date: 2020-06-01 17:57:30
Modify Date: 2024-01-12 04:13:30
PROTAC BRD4-binding moiety 1 is a ligand for BRD4. PROTAC BRD4-binding moiety 1 binds to cereblon ligand via a linker to form PROTAC to degrade BRD4 (HY-133136)[1].

Name	PROTAC BRD4-binding moiety 1

Description	PROTAC BRD4-binding moiety 1 is a ligand for BRD4. PROTAC BRD4-binding moiety 1 binds to cereblon ligand via a linker to form PROTAC to degrade BRD4 (HY-133136)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain
Target	BRD4
In Vitro	PROTAC BRD4 Degrader-2 is an efficacious PROTAC BRD4 degrader with an IC50 of 14.2 nM against BRD4 BD1[1].
References	[1]. Zhang F, et al. Discovery of a new class of PROTAC BRD4 degraders based on a dihydroquinazolinone derivative and lenalidomide/pomalidomide. Bioorg Med Chem. 2020 Jan 1;28(1):115228.