1781941-93-2

1781941-93-2 structure

Name: ROS 234 dioxalate
Chemical Name: ROS 234 dioxalate
CAS Number: 1781941-93-2
Molecular Formula: C₁₇H₁₉N₅O₈
Molecular Weight: 421.36
Catalog: Signaling Pathways GPCR/G Protein Histamine Receptor
Create Date: 2020-06-01 12:22:53
Modify Date: 2024-09-19 15:02:26
ROS 234 dioxalate is a potent H3 antagonist, with a pKB of 9.46 for Guinea-pig ileum H3-receptor, a pKi of 8.90 for Rat cerebral cortex H3-receptor, and a ED50 of 19.12 mg/kg (ip) in ex vivo of Rat cerebral cortex. ROS 234 dioxalate diaplays poor central access[1][2].

Name	ROS 234 dioxalate

Description	ROS 234 dioxalate is a potent H3 antagonist, with a pKB of 9.46 for Guinea-pig ileum H3-receptor, a pKi of 8.90 for Rat cerebral cortex H3-receptor, and a ED50 of 19.12 mg/kg (ip) in ex vivo of Rat cerebral cortex. ROS 234 dioxalate diaplays poor central access[1][2].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Inflammation/Immunology Signaling Pathways >> GPCR/G Protein >> Histamine Receptor
Target	H2 Receptor:8.90 (pKi, Rat cerebral cortex H3-receptor)
In Vivo	ROS 234, centrally injected, significantly shortens pentobarbital narcosis[1].
References	[1]. Ballabeni V, et al. CNS access of selected H3-antagonists: ex vivo binding study in rats. Inflamm Res. 2002 Apr;51 Suppl 1:S55-6. [2]. Mor M, et al. Synthesis, biological activity, QSAR and QSPR study of 2-aminobenzimidazole derivatives as potent H3-antagonists. Bioorg Med Chem. 2004 Feb 15;12(4):663-74.

Molecular Formula	C₁₇H₁₉N₅O₈
Molecular Weight	421.36