1333126-31-0
1333126-31-0 structure
- Name: Azvudine hydrochloride
- Chemical Name: Azvudine hydrochloride
- CAS Number: 1333126-31-0
- Molecular Formula: C9H12ClFN6O4
- Molecular Weight: 322.68
- Catalog: Signaling Pathways Anti-infection HBV
- Create Date: 2020-08-09 07:46:15
- Modify Date: 2024-01-06 19:30:39
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Azvudine (RO-0622) hydrochloride is a potent nucleoside reverse transcriptase inhibitor (NRTI), with antiviral activity on HIV, HBV and HCV. Azvudine hydrochloride exerts highly potent inhibition on HIV-1 (EC50s ranging from 0.03 to 6.92 nM) and HIV-2 (EC50s ranging from 0.018 to 0.025 nM). Azvudine hydrochloride inhibits NRTI-resistant viral strains[1].
| Name | Azvudine hydrochloride |
|---|
| Description | Azvudine (RO-0622) hydrochloride is a potent nucleoside reverse transcriptase inhibitor (NRTI), with antiviral activity on HIV, HBV and HCV. Azvudine hydrochloride exerts highly potent inhibition on HIV-1 (EC50s ranging from 0.03 to 6.92 nM) and HIV-2 (EC50s ranging from 0.018 to 0.025 nM). Azvudine hydrochloride inhibits NRTI-resistant viral strains[1]. |
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| Related Catalog | |
| Target |
HIV-1:0.03-6.92 nM (EC50) HIV-2:0.018-0.02 nM (EC50) |
| In Vitro | Azvudine (RO-0622) hydrochloride displays strong inhibition on wild-type HIV-1IIIB and HIV-1RF with an EC50 ranging from 30 to 110 pM. The EC50 values of Azvudine hydrochloride against HIV-1KM018, HIV-1TC-1 and HIV-1WAN T69N are 6.92, 0.34 and 0.45 nM, respectively. Azvudine is sensitive to NRTIs-resistant strain HIV-174V, PIs-resistant strains HIV-1L10R/M46I/L63P/V82T/I84V and HIV-1RF V82F/184V, and FIs-resistant strain pNL4-3gp41 (36G) V38A/N42T. The EC50 values of Azvudine hydrochloride against these resistant strains are 0.11, 0.14, 0.37 and 0.36 nM respectively[1]. |
| References |
| Molecular Formula | C9H12ClFN6O4 |
|---|---|
| Molecular Weight | 322.68 |