2226521-64-6

2226521-64-6 structure

Name: FM-479
Chemical Name: FM-479
CAS Number: 2226521-64-6
Molecular Formula: C₂₅H₂₆N₆O₂
Molecular Weight: 442.51
Catalog: Signaling Pathways Epigenetics JAK
Create Date: 2020-08-07 20:25:39
Modify Date: 2024-01-14 02:45:23
FM-479 is the negative control of FM-381 (HY-102046) and has no activity on JAK3 or other kinases[1]. FM-381 is a potent covalent reversible inhibitor of JAK3 targeting the unique Cys909. FM-381 has an IC50 of 127 pM for JAK3, with 410, 2700 and 3600-fold selectivity over JAK1, JAK2 and TYK2, respectively.

Name	FM-479

Description	FM-479 is the negative control of FM-381 (HY-102046) and has no activity on JAK3 or other kinases[1]. FM-381 is a potent covalent reversible inhibitor of JAK3 targeting the unique Cys909. FM-381 has an IC50 of 127 pM for JAK3, with 410, 2700 and 3600-fold selectivity over JAK1, JAK2 and TYK2, respectively.
Related Catalog	Signaling Pathways >> JAK/STAT Signaling >> JAK Signaling Pathways >> Epigenetics >> JAK Signaling Pathways >> Stem Cell/Wnt >> JAK Research Areas >> Inflammation/Immunology
Target	JAK3
In Vitro	FM-479 is the inactive control of FM-381, the concentration used in assays is similar[1].
References	[1]. https://www.thesgc.org/chemical-probes/FM-381

Molecular Formula	C₂₅H₂₆N₆O₂
Molecular Weight	442.51