1172089-00-7

1172089-00-7 structure

Name: M 1145 TFA
Chemical Name: M1145
CAS Number: 1172089-00-7
Molecular Formula: C₁₂₈H₂₀₅N₃₇O₃₂
Molecular Weight: 2774.23
Catalog: Signaling Pathways GPCR/G Protein Neuropeptide Y Receptor
Create Date: 2020-08-10 22:13:39
Modify Date: 2024-01-09 18:50:07
M1145, a chimeric peptide, is a selective galanin receptor type 2 (GAL2) agonist, with a Ki of 6.55 nM. M1145 shows more than 90-fold higher affinity for GAL2 over GAL1 (Ki=587 nM) and a 76-fold higher affinity over GalR3 (Ki=497 nM). M1145 has an additive effect on the signal transduction of galanin[1].

Name	M1145

Description	M1145, a chimeric peptide, is a selective galanin receptor type 2 (GAL2) agonist, with a Ki of 6.55 nM. M1145 shows more than 90-fold higher affinity for GAL2 over GAL1 (Ki=587 nM) and a 76-fold higher affinity over GalR3 (Ki=497 nM). M1145 has an additive effect on the signal transduction of galanin[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Neuropeptide Y Receptor
In Vitro	M1145 has an additive effect on the signal transduction of galanin, are concentrations of M1145 of 0.1 μM and higher all give a maximum transduction. Signal transduction was examined by assessing the ability to stimulate inositol phosphates (IP) production in CHO cells expressing GalR2. Treatment with M1145, which stimulates IP production with an EC50 of 38 nM[1].
References	[1]. Runesson J, Saar I, Lundström L, Järv J, Langel U. A novel GalR2-specific peptide agonist. Neuropeptides. 2009;43(3):187-192.

Molecular Formula	C₁₂₈H₂₀₅N₃₇O₃₂
Molecular Weight	2774.23