196391-82-9

196391-82-9 structure

Name: Prosaptide Tx14(A) TFA
Chemical Name: Prosaptide Tx14(A)
CAS Number: 196391-82-9
Molecular Formula: C₆₉H₁₁₀N₁₆O₂₆
Molecular Weight: 1579.70
Catalog: Research Areas Neurological Disease
Create Date: 2020-08-10 19:39:10
Modify Date: 2024-01-05 17:09:49
Prosaptide Tx14(A), a prosaposin-derived peptide, is a potent GPR37L1 and GPR37 agonist with EC50s of 5 and 7 nM, respectively. Prosaptide Tx14(A) increases both ERK1 and ERK2 phosphorylation in Schwann cells[1][2].

Name	Prosaptide Tx14(A)

Description	Prosaptide Tx14(A), a prosaposin-derived peptide, is a potent GPR37L1 and GPR37 agonist with EC50s of 5 and 7 nM, respectively. Prosaptide Tx14(A) increases both ERK1 and ERK2 phosphorylation in Schwann cells[1][2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
In Vitro	Prosaptide Tx14(A) promotes the endocytosis of GPR37 and GPR37L1, bound to both receptors and activated signaling in a GPR37- and GPR37L1-dependent manner. Prosaptide Tx14(A) is the active fragment of the secreted neuroprotective and glioprotective factor prosaposin (also known as sulfated glycoprotein-1)[1].
References	[1]. Meyer RC, et al. GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin. Proc Natl Acad Sci U S A. 2013;110(23):9529-9534. [2]. Campana WM, et al. Prosaptide activates the MAPK pathway by a G-protein-dependent mechanism essential for enhanced sulfatide synthesis by Schwann cells. FASEB J. 1998;12(3):307-314.

Molecular Formula	C₆₉H₁₁₀N₁₆O₂₆
Molecular Weight	1579.70