1336913-03-1
1336913-03-1 structure
- Name: PSEM 89S TFA
- Chemical Name: PSEM 89S TFA
- CAS Number: 1336913-03-1
- Molecular Formula: C18H23F3N2O5
- Molecular Weight: 404.38
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel nAChR
- Create Date: 2020-08-10 21:11:37
- Modify Date: 2024-01-17 08:06:21
-
PSEM 89S TFA is a selective and brain penetrant agonists for the resulting ion channels. PSEM 89S TFA is orthogonally selective for Q79G and L141F, respectively[1].
| Name | PSEM 89S TFA |
|---|
| Description | PSEM 89S TFA is a selective and brain penetrant agonists for the resulting ion channels. PSEM 89S TFA is orthogonally selective for Q79G and L141F, respectively[1]. |
|---|---|
| Related Catalog | |
| In Vitro | PSEM 89S (10 or 30μM) activates layer 2/3 cortical neurons expressing (Pharmacologically Selective Actuator Module) PSAML141F,Y115F-5HT3 high conductance (HC)[1]. PSEM 89S (10 μM) reversibly silenced transfected neurons by reducing cellular input resistance[1]. |
| In Vivo | PSEM 89S strongly reduces photostimulation-evoked feeding in mice expressing PSAML141F,Y115F- glycine receptor (GlyR) (30 mg/kg) but not in mice expressing only channelrhodopsin-2 (ChR2) (50 mg/kg)[1]. PSEM 89S (30 mg/kg) shows good brain penetrance in mice after minimally invasive intraperitoneal administration[1]. Animal Model: Male Agrp-cre mice (3-6 weeks)[1] Dosage: 30 mg/kg Administration: I.p. administration Result: Almost completely suppressed fos (a marker of neuron activation) in ChR2-expressing neurons. Animal Model: C57BL/6 mice[1] Dosage: 30 mg/kg (Pharmacokinetic Analysis) Administration: I.p. administration Result: Rised rapidly in serum and brain, and was mostly cleared from both compartments in 1 h. |
| References |
| Molecular Formula | C18H23F3N2O5 |
|---|---|
| Molecular Weight | 404.38 |