1446322-66-2

1446322-66-2 structure

Name: TAT-cyclo-CLLFVY TFA
Chemical Name: TAT-cyclo-CLLFVY
CAS Number: 1446322-66-2
Molecular Formula: C₁₁₆H₁₇₆N₃₂O₃₃
Molecular Weight: 2546.86
Catalog: Signaling Pathways Metabolic Enzyme/Protease HIF/HIF Prolyl-Hydroxylase
Create Date: 2020-08-11 00:06:29
Modify Date: 2024-01-14 20:25:21
TAT-cyclo-CLLFVY is a selective HIF-1 dimerization inhibitor. TAT-cyclo-CLLFVY blocks protein-protein interaction of recombinant HIF-1α, but not HIF-2α, with HIF-1β (IC50=1.3 μM). TAT-cyclo-CLLFVY inhibits hypoxia-induced HIF-1 activity, and decreases VEGF and CAIX expression in osteosarcoma and breast cancer cells in vitro. TAT-cyclo-CLLFVY also reduces tubularization of hypoxic HUVECs.

Name	TAT-cyclo-CLLFVY

Description	TAT-cyclo-CLLFVY is a selective HIF-1 dimerization inhibitor. TAT-cyclo-CLLFVY blocks protein-protein interaction of recombinant HIF-1α, but not HIF-2α, with HIF-1β (IC50=1.3 μM). TAT-cyclo-CLLFVY inhibits hypoxia-induced HIF-1 activity, and decreases VEGF and CAIX expression in osteosarcoma and breast cancer cells in vitro. TAT-cyclo-CLLFVY also reduces tubularization of hypoxic HUVECs.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> HIF/HIF Prolyl-Hydroxylase

Molecular Formula	C₁₁₆H₁₇₆N₃₂O₃₃
Molecular Weight	2546.86

Hazard Codes	Xi