581099-89-0

581099-89-0 structure

Name: UMB 68
Chemical Name: UMB68 sodium
CAS Number: 581099-89-0
Molecular Formula: C₆H₁₁NaO₃
Molecular Weight: 154.14
Catalog: Research Areas Neurological Disease
Create Date: 2020-08-11 14:41:33
Modify Date: 2024-01-12 12:10:05
UMB68 sodium is a selective GHB receptor ligand. UMB68 sodium displaces [3H]NCS-382 with an IC50 of 38 nM in rat cerebrocortical membranes. UMB68 sodium has no significant affinity at GABAB receptors, cannot be metabolized to GABA-active compounds[1].

Name	UMB68 sodium

Description	UMB68 sodium is a selective GHB receptor ligand. UMB68 sodium displaces [3H]NCS-382 with an IC50 of 38 nM in rat cerebrocortical membranes. UMB68 sodium has no significant affinity at GABAB receptors, cannot be metabolized to GABA-active compounds[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
Target	GHB receptor[1]
In Vitro	UMB68 inhibits [3H]NCS382 (16 nM) binding to the rat cerebrocortical membranes, with an IC50 of 38 nM compared with 25 μM for GHB[1]. UMB68 showes no affinity (IC50 >100 μM) at GABA(A) or GABA(B) receptors[1].
In Vivo	UMB68 (320-1778 mg/kg; i.p.) decreases markedly lever pressing in rats[1]. Animal Model: Adult male Sprague-Dawley rats (250-300 g) are carried out discrimination training[1] Dosage: 320, 660, 1000, 1778 mg/kg Administration: I.p. injection Result: Caused vehicle-lever responding up to a dose (1778 mg/kg) that decreased markedly or eliminated lever pressing.
References	[1]. Wu H, et, al. A tertiary alcohol analog of gamma-hydroxybutyric acid as a specific gamma-hydroxybutyric acid receptor ligand. J Pharmacol Exp Ther. 2003 May;305(2):675-9.

Molecular Formula	C₆H₁₁NaO₃
Molecular Weight	154.14