188640-63-3
188640-63-3 structure
- Name: 4-Ethynyl-L-phenylalanine hydrochloride
- Chemical Name: 4-Ethynyl-L-phenylalanine hydrochloride
- CAS Number: 188640-63-3
- Molecular Formula: C11H12ClNO2
- Molecular Weight: 225.67
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Tryptophan Hydroxylase
- Create Date: 2020-10-18 18:07:30
- Modify Date: 2024-01-11 19:46:56
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4-Ethynyl-L-phenylalanine hydrochloride is a selective, reversible, potent and competitive inhibitor of tryptophan hydroxylase (TPH). 4-Ethynyl-L-phenylalanine hydrochloride is a competitive inhibitor with regard to the substrate tryptophan, with a Ki of 32.6 μM. 4-Ethynyl-L-phenylalanine hydrochloride selectively and reversibly inhibits the biosynthesis of serotonin[1].
| Name | 4-Ethynyl-L-phenylalanine hydrochloride |
|---|
| Description | 4-Ethynyl-L-phenylalanine hydrochloride is a selective, reversible, potent and competitive inhibitor of tryptophan hydroxylase (TPH). 4-Ethynyl-L-phenylalanine hydrochloride is a competitive inhibitor with regard to the substrate tryptophan, with a Ki of 32.6 μM. 4-Ethynyl-L-phenylalanine hydrochloride selectively and reversibly inhibits the biosynthesis of serotonin[1]. |
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| Related Catalog | |
| Target |
Ki: 32.6 μM (TPH)[1] |
| In Vivo | 4-Ethynyl-L-phenylalanine hydrochloride (30 mg/kg; i.p.) decreases in 5-HT and 5-HIAA levels in the rat midbrain but not in tissue[1]. 4-Ethynyl-L-phenylalanine hydrochloride is not inhibiting the aromatic amino acid decarboxylase[1]. 4-Ethynyl-L-phenylalanine hydrochloride has a low affinity for various recombinant 5-HT receptors[1]. Animal Model: Male Sprague-Dawley rats (200 g)[1] Dosage: 30 mg/kg Administration: Intraperitoneal injection Result: Decreased in 5-HT and 5-HIAA levels in the rat midbrain. |
| References |
| Molecular Formula | C11H12ClNO2 |
|---|---|
| Molecular Weight | 225.67 |