1383719-97-8

1383719-97-8 structure

Name: PF 04628935
Chemical Name: 1-{2-[2-Chloro-4-(2H-1,2,3-triazol-2-yl)benzyl]-2,7-diazaspiro[3.5]non-7-yl}-2-(2-methylimidazo[2,1-b][1,3]thiazol-6-yl)ethanone
CAS Number: 1383719-97-8
Molecular Formula: C₂₄H₂₆ClN₇OS
Molecular Weight: 496.03
Catalog: Signaling Pathways GPCR/G Protein GHSR
Create Date: 2021-01-10 17:59:41
Modify Date: 2024-01-17 10:32:48
PF-04628935 (compound 10n) is a potent ghrelin receptor inverse agonist, with an IC50 of 4.6 nM. PF-04628935 exhibits oral bioavailability of 43% in rats and shows reasonable penetration into the brain. PF-04628935 can be used for stress and anxiety research[1][2].

Name	1-{2-[2-Chloro-4-(2H-1,2,3-triazol-2-yl)benzyl]-2,7-diazaspiro[3.5]non-7-yl}-2-(2-methylimidazo[2,1-b][1,3]thiazol-6-yl)ethanone
Synonyms	1-{2-[2-Chloro-4-(2H-1,2,3-triazol-2-yl)benzyl]-2,7-diazaspiro[3.5]non-7-yl}-2-(2-methylimidazo[2,1-b][1,3]thiazol-6-yl)ethanone Ethanone, 1-[2-[[2-chloro-4-(2H-1,2,3-triazol-2-yl)phenyl]methyl]-2,7-diazaspiro[3.5]non-7-yl]-2-(2-methylimidazo[2,1-b]thiazol-6-yl)-

Description	PF-04628935 (compound 10n) is a potent ghrelin receptor inverse agonist, with an IC50 of 4.6 nM. PF-04628935 exhibits oral bioavailability of 43% in rats and shows reasonable penetration into the brain. PF-04628935 can be used for stress and anxiety research[1][2].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> GHSR
Target	GHSR1a:4.6 nM (IC50)
References	[1]. Kung DW, et, al. Identification of spirocyclic piperidine-azetidine inverse agonists of the ghrelin receptor. Bioorg Med Chem Lett. 2012 Jul 1;22(13):4281-7. [2]. Cavalcante DP, et, al. Role of dorsal raphe nucleus GHS-R1a receptors in the regulation of inhibitory avoidance and escape behaviors in rats. Behav Brain Res. 2019 Jun 3;365:178-184.

RIDADR	NONH for all modes of transport