Shanghai Nianxing Industrial Co., Ltd
China
Product Name: PKCε Inhibitor Peptide
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Purity: 98.0%
Stocking Period: 10 Day
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ShangHai DC Chemicals Co.,Ltd
China
Product Name: Epsilon-V1-2
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Lai

DC Chemicals Limited
China
Product Name: Epsilon-V1-2
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
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Taiwan Oyi peptide Co. Ltd
China
Product Name: Epsilon-V1-2
Price: $Inquiry/1mg $Inquiry/100kg
Purity: 98.0%
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Contact: Vinnie

182683-50-7

182683-50-7 structure

182683-50-7 structure

Name: Epsilon-V1-2
Chemical Name: PKCε Inhibitor Peptide
CAS Number: 182683-50-7
Molecular Formula: C₃₇H₆₅N₉O₁₃
Molecular Weight: 843.964
Catalog: Signaling Pathways Epigenetics PKC
Create Date: 2021-05-10 23:22:30
Modify Date: 2024-01-02 00:52:08
Epsilon-V1-2 (ε-V1-2), a PKCε-derived peptide, is a selective PKCε inhibitor. Epsilon-V1-2 inhibits the translocationof PKCε, but not α-, β-, and δPKC[1].

Name	PKCε Inhibitor Peptide
Synonyms	L-Threonine, L-α-glutamyl-L-alanyl-L-valyl-L-seryl-L-leucyl-L-lysyl-L-prolyl- L-α-Glutamyl-L-alanyl-L-valyl-L-seryl-L-leucyl-L-lysyl-L-prolyl-L-threonine PKCÎµ Inhibitor Peptide

Description	Epsilon-V1-2 (ε-V1-2), a PKCε-derived peptide, is a selective PKCε inhibitor. Epsilon-V1-2 inhibits the translocationof PKCε, but not α-, β-, and δPKC[1].
Related Catalog	Signaling Pathways >> Epigenetics >> PKC Research Areas >> Inflammation/Immunology Signaling Pathways >> TGF-beta/Smad >> PKC
Target	PKCε
In Vitro	Epsilon-V1-2 (ε-V1-2), a PKCε-derived peptide containing the site for its specific receptor for activated C kinase (RACK), inhibits translocation of PKCε and reduces insulin response to glucose[1]. Epsilon-V1-2 (ε-V1-2; 1 µM, 24 hours) treatment significantly inhibits Oleic acid (OA)-induced connexin 43 (Cx43) Ser368 phosphorylation and prevents OA-induced gap junction disassembly in cardiomyocytes[2].
In Vivo	Epsilon-V1-2 (20 mg/kg/day; osmotic pumps; daily; for 4 weeks) treatment significantly improves the beating score in a murine heterotopic transplantation model. Epsilon-V1-2 reduces infiltration of macrophages and T cells into the cardiac grafts, and decreases parenchymal fibrosis. Epsilon-V1-2 treatment almost abolishes the rise in pro-fibrotic cytokine, TGF-β and monocyte recruiting chemokine MCP-1 levels[3]. Animal Model: C57BL/6J mice transplanted the hearts of FVB mice[3] Dosage: 20 mg/kg/day Administration: 0.1 mL osmotic pumps implanted subcutaneously; daily; for 4 weeks Result: Significantly improved the beating score throughout the treatment.
References	[1]. M Yedovitzky, et al. Translocation inhibitors define specificity of protein kinase C isoenzymes in pancreatic beta-cells. J Biol Chem. 1997 Jan 17;272(3):1417-20. [2]. Yuahn-Sieh Huang, et al. Mechanism of oleic acid-induced gap junctional disassembly in rat cardiomyocytes. J Mol Cell Cardiol. 2004 Sep;37(3):755-66. [3]. Tomoyoshi Koyanagi, et al. Pharmacological inhibition of epsilon PKC suppresses chronic inflammation in murine cardiac transplantation model. J Mol Cell Cardiol. 2007 Oct;43(4):517-22.

Density	1.3±0.1 g/cm3
Boiling Point	1280.1±65.0 °C at 760 mmHg
Molecular Formula	C₃₇H₆₅N₉O₁₃
Molecular Weight	843.964
Flash Point	728.0±34.3 °C
Exact Mass	843.470154
LogP	-1.22
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.552