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  • DC Chemicals Limited
  • China
  • Product Name: IMM-H007
  • Price: ¥700.0/100mg ¥1300.0/250mg ¥2500.0/1g ¥220.0/10ml
  • Purity: 98.0%
  • Stocking Period: 1 Day
  • Contact: Tony Cao

1221412-23-2

1221412-23-2 structure
1221412-23-2 structure
  • Name: IMM-H007
  • Chemical Name: IMM-H007
  • CAS Number: 1221412-23-2
  • Molecular Formula: C22H23N5O8
  • Molecular Weight: 485.45
  • Catalog: Signaling Pathways Epigenetics AMPK
  • Create Date: 2021-05-23 14:38:10
  • Modify Date: 2024-01-04 14:41:35
  • IMM-H007 is a potent TGFβ1 (transforming growth factor β1) antagonist. IMM-H007 has protective effects in cardiovascular diseases via activation of AMPK (AMP-activated protein kinase). IMM-H007 negatively regulates endothelium inflammation through inactivating NF-κB and JNK/AP1 signaling. IMM-H007 inhibits ABCA1 degradation. IMM-H007 resolves hepatic steatosis in HFD-fed hamsters by the regulation of lipid metabolism. IMM-H007 can be used for the research of nonalcoholic fatty liver disease (NAFLD) and inflammatory atherosclerosis[1][2][3].

Name IMM-H007
Description IMM-H007 is a potent TGFβ1 (transforming growth factor β1) antagonist. IMM-H007 has protective effects in cardiovascular diseases via activation of AMPK (AMP-activated protein kinase). IMM-H007 negatively regulates endothelium inflammation through inactivating NF-κB and JNK/AP1 signaling. IMM-H007 inhibits ABCA1 degradation. IMM-H007 resolves hepatic steatosis in HFD-fed hamsters by the regulation of lipid metabolism. IMM-H007 can be used for the research of nonalcoholic fatty liver disease (NAFLD) and inflammatory atherosclerosis[1][2][3].
Related Catalog
In Vivo IMM-H007 inhibits fatty acid import into hepatocytes and liver lipogenesis, and concomitantly stimulates fatty acid oxidation, autophagy, and export of hepatic lipids[2].
References

[1]. Yu J, et al. IMM-H007, a novel small molecule inhibitor for atherosclerosis, represses endothelium inflammation by regulating the activity of NF-κB and JNK/AP1 signaling. Toxicol Appl Pharmacol. 2019 Oct 15;381:114732.

[2]. Shi H, et al. IMM-H007, a new therapeutic candidate for nonalcoholic fatty liver disease, improves hepatic steatosis in hamsters fed a high-fat diet. FEBS Open Bio. 2017 Aug 29;7(9):1379-1391.

[3]. Wang SX, et al. IMM-H007 attenuates isoprenaline-induced cardiac fibrosis through targeting TGFβ1 signaling pathway. Acta Pharmacol Sin. 2022 Mar 30.

Density 1.54±0.1 g/cm3
Boiling Point 684.6±65.0 °C
Molecular Formula C22H23N5O8
Molecular Weight 485.45
Storage condition -20°C