2140807-23-2

2140807-23-2 structure

Name: Thalidomide-NH-C2-PEG3-OH
Chemical Name: Thalidomide-NH-C2-PEG3-OH
CAS Number: 2140807-23-2
Molecular Formula: C₂₁H₂₇N₃O₈
Molecular Weight: 449.45
Catalog: Signaling Pathways PROTAC E3 Ligase Ligand-Linker Conjugate
Create Date: 2021-08-09 14:39:23
Modify Date: 2024-01-14 20:20:35
Thalidomide-NH-C2-PEG3-OH is an E3 ligase ligand-linker conjugate that incorporates Thalidomide based cereblon ligand and a linker used for PROTAC BCL-XL degrader XZ739[1].

Name	Thalidomide-NH-C2-PEG3-OH

Description	Thalidomide-NH-C2-PEG3-OH is an E3 ligase ligand-linker conjugate that incorporates Thalidomide based cereblon ligand and a linker used for PROTAC BCL-XL degrader XZ739[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> E3 Ligase Ligand-Linker Conjugate
Target	Cereblon
In Vitro	XZ739, a CRBN-dependent PROTAC BCL-XL degrader with a DC50 value of 2.5 nM in MOLT-4 cells after 16 h treatment. XZ739 also induces cell death through caspase-mediated apoptosis[1].
References	[1]. Xuan Zhang,et al. Discovery of PROTAC BCL-X L Degraders as Potent Anticancer Agents With Low On-Target Platelet Toxicity. Eur J Med Chem. 2020 Apr 15;192:112186.

Molecular Formula	C₂₁H₂₇N₃O₈
Molecular Weight	449.45

Hazard Codes	Xi