Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Isoxepac
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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Isoxepac
Price: ￥598.0/25g ￥78.0/1g ￥188.0/5g
Purity: 97.0%
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ShangHai DC Chemicals Co.,Ltd
China
Product Name: Isoxepac
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DC Chemicals Limited
China
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Henan Tianfu Chemical Co., Ltd.
China
Product Name: TIANFU-CHEM 55453-87-7 Isoxepac
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55453-87-7

55453-87-7 structure

Name: Isoxepac
Chemical Name: 2-(11-Oxo-6,11-dihydrodibenzo[b,e]oxepin-2-yl)acetic acid
CAS Number: 55453-87-7
Molecular Formula: C₁₆H₁₂O₄
Molecular Weight: 268.264
Catalog: analytical chemistry Standard Pharmacopoeia Standards and Magazine Standards
Create Date: 2018-08-02 18:15:58
Modify Date: 2024-01-02 17:06:42
Isoxepac (HP 549) is a nonsteroidal anti-inflammatory agent (NSAID) with anti-inflammatory, analgesic and antipyretic activity. Isoxepac has been studied in rat, rabbit, dog, rhesus monkey, etc[1][2][3].

Name	2-(11-Oxo-6,11-dihydrodibenzo[b,e]oxepin-2-yl)acetic acid
Synonyms	6,11-dihydro-11-oxo-dibenz[b,e]oxepin-2-acetic acid Dibenz[b,e]oxepin-2-acetic acid, 6,11-dihydro-11-oxo- Isoxepac MFCD00242952 (11-Oxo-6,11-dihydrodibenzo[b,e]oxepin-2-yl)acetic acid Artil

Description	Isoxepac (HP 549) is a nonsteroidal anti-inflammatory agent (NSAID) with anti-inflammatory, analgesic and antipyretic activity. Isoxepac has been studied in rat, rabbit, dog, rhesus monkey, etc[1][2][3].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
References	[1]. L S Gerlis, et al. Isoxepac in rheumatoid arthritis: a double-blind comparison with aspirin. Rheumatol Rehabil. 1981 Feb 1;20(1):50-3. [2]. W J Honig, et al. Analgesic effect of isoxepac on postmeniscectomy pain: a controlled trial. J Clin Pharmacol. Feb-Mar 1982;22(2-3):82-8. [3]. H P Illing, et al. Species differences in the disposition and metabolism of 6,11-dihydro-11-oxodibenz[be]oxepin-2-acetic acid (isoxepac) in rat, rabbit, dog, rhesus monkey, and man. Drug Metab Dispos. Sep-Oct 1978;6(5):510-7.

Density	1.3±0.1 g/cm3
Boiling Point	528.2±50.0 °C at 760 mmHg
Melting Point	130-132ºC
Molecular Formula	C₁₆H₁₂O₄
Molecular Weight	268.264
Flash Point	203.8±23.6 °C
Exact Mass	268.073547
PSA	63.60000
LogP	2.64
Vapour Pressure	0.0±1.5 mmHg at 25°C
Index of Refraction	1.636
Storage condition	Refrigerator

CHEMICAL IDENTIFICATION

RTECS NUMBER :: HQ4110000

CHEMICAL NAME :: Dibenz(b,e)oxepin-2-acetic acid, 6,11-dihydro-11-oxo-

CAS REGISTRY NUMBER :: 55453-87-7

BEILSTEIN REFERENCE NO. :: 1320243

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C16-H12-O4

MOLECULAR WEIGHT :: 268.28

WISWESSER LINE NOTATION :: T C676 BV IO JHJ E1VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 143 mg/kg

TOXIC EFFECTS :: Gastrointestinal - ulceration or bleeding from stomach Gastrointestinal - ulceration or bleeding from small intestine

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 227,142,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Gastrointestinal - ulceration or bleeding from stomach Gastrointestinal - ulceration or bleeding from small intestine

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 227,142,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 240 mg/kg

TOXIC EFFECTS :: Gastrointestinal - ulceration or bleeding from stomach Gastrointestinal - ulceration or bleeding from small intestine

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 227,142,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 160 mg/kg

TOXIC EFFECTS :: Gastrointestinal - ulceration or bleeding from stomach Gastrointestinal - ulceration or bleeding from small intestine

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 227,142,1977

Hazard Codes	T
Risk Phrases	25-62
Safety Phrases	36/37-45
HS Code	2942000000

55453-89-9

~98%

55453-87-7

Literature: EP2072507 A1, ; Page/Page column 10-11 ;

69031-39-6

55453-87-7

Literature: US4118401 A1, ;

2417-73-4

55453-87-7

Literature: Journal of Medicinal Chemistry, , vol. 39, # 1 p. 246 - 252

17138-28-2

55453-87-7

Literature: Journal of Medicinal Chemistry, , vol. 39, # 1 p. 246 - 252

156-38-7

55453-87-7

Literature: WO2011/128911 A2, ;

87-41-2

55453-87-7

Literature: WO2011/128911 A2, ;

Precursor 5
55453-89-9 2417-73-4 17138-28-2 156-38-7
87-41-2
DownStream 2
55689-64-0 140462-76-6

HS Code	2932999099
Summary	2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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