113806-05-6

113806-05-6 structure

Name: Olopatadine
Chemical Name: Olopatadine
CAS Number: 113806-05-6
Molecular Formula: C₂₁H₂₃NO₃
Molecular Weight: 337.412
Catalog: API Antiallergic Antihistamine
Create Date: 2018-02-24 08:00:00
Modify Date: 2024-01-02 10:33:41
Olopatadine is an orally active and selective histamine 1 (H1) receptor antagonist and a mast cell stabilizer. Olopatadine prevents immunologically stimulated pro-inflammatory mediator release from human conjunctival mast cells. Olopatadine can be used for researching allergic conjunctivitis[1][2].

Name	Olopatadine
Synonyms	{(11E)-11-[3-(Dimethylamino)propylidene]-6,11-dihydrodibenzo[b,e]oxepin-2-yl}acetic acid Dibenz[b,e]oxepin-2-acetic acid, 11-[3-(dimethylamino)propylidene]-6,11-dihydro-, (11E)- MFCD00865645 KW 4679 Olopatatadine

Description	Olopatadine is an orally active and selective histamine 1 (H1) receptor antagonist and a mast cell stabilizer. Olopatadine prevents immunologically stimulated pro-inflammatory mediator release from human conjunctival mast cells. Olopatadine can be used for researching allergic conjunctivitis[1][2].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Inflammation/Immunology Signaling Pathways >> GPCR/G Protein >> Histamine Receptor
Target	H1 Receptor
In Vitro	Olopatadine inhibits anti-IgE antibody-mediated release of TNF-α from human conjunctival mast cells, and significantly decreases the mast cell supernatant-mediated upregulation of ICAM (intercellular adhesion molecule)-1 on human conjunctival epithelial cells in vitro[2].
References	[1]. Kam KW, et al. Topical Olopatadine in the Treatment of Allergic Conjunctivitis: A Systematic Review and Meta-analysis. Ocul Immunol Inflamm. 2017 Oct;25(5):663-677. [2]. Leonardi A, et al. Olopatadine: a drug for allergic conjunctivitis targeting the mast cell. Expert Opin Pharmacother. 2010 Apr;11(6):969-81.

113806-01-2

~89%

113806-05-6

Literature: WO2006/10459 A1, ; Page/Page column 14-15 ;

1123338-92-0

~45%

113806-05-6

Literature: WO2010/89268 A2, ; Page/Page column 13-14 ;

951006-73-8

~99%

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Literature: US2007/232814 A1, ; Page/Page column 25; 26 ;

1253179-74-6

113806-05-6

Literature: WO2010/121877 A2, ; Page/Page column 25-26 ;

19070-16-7

113806-05-6

113806-06-7

Literature: EP2385045 A1, ;