87893-55-8

87893-55-8 structure

Name: 15-Deoxy-Delta12
Chemical Name: 15d-pgj2
CAS Number: 87893-55-8
Molecular Formula: C₂₀H₂₈O₃
Molecular Weight: 316.435
Catalog: Signaling Pathways Cell Cycle/DNA Damage PPAR
Create Date: 2018-12-29 17:09:42
Modify Date: 2024-01-02 11:27:33
15-Deoxy-Δ-12,14-prostaglandin J2 (15d-PGJ2) is a cyclopentenone prostaglandin and a metabolite of PGD2. 15-Deoxy-Δ-12,14-prostaglandin J2 is a selective PPARγ (EC50 of 2 µM) and a covalent PPARδ agonist. 15-Deoxy-Δ-12,14-prostaglandin J2 promotes efficient differentiation of C3H10T1/2 fibroblasts to adipocytes with an EC50 of 7 μM[1][2].

Name	15d-pgj2
Synonyms	delta12,14-Pgj 2 15-Deoxy-D-12,14-prostaglandin J2 Prosta-5,9,12,14-tetraen-1-oic acid, 11-oxo-, (5Z,12E,14E)- 15-Deoxy-D12,14-PGJ2 PROSTAGLANDIN J2,15-DEOXY-DELTA12,14 11-OXO-PROSTA-5Z,9,12E,14Z-TETRAEN-1-OIC 15-DEOXY-DELTA12,14-PROSTAGLANGIN J2 15-DEOXY-DELTA12,14-PGJ2 MFCD00065806 15-DEOXY-DELTA12,DELTA14-PROSTAGLANDIN J2 (5Z,12E,14E)-11-Oxo-prosta-5,9,12,14-tetraen-1-oic acid 15-Deoxy-delta12,14-prostaglandin (5Z,12E,14E)-11-Oxoprosta-5,9,12,14-tetraen-1-oic acid

Description	15-Deoxy-Δ-12,14-prostaglandin J2 (15d-PGJ2) is a cyclopentenone prostaglandin and a metabolite of PGD2. 15-Deoxy-Δ-12,14-prostaglandin J2 is a selective PPARγ (EC50 of 2 µM) and a covalent PPARδ agonist. 15-Deoxy-Δ-12,14-prostaglandin J2 promotes efficient differentiation of C3H10T1/2 fibroblasts to adipocytes with an EC50 of 7 μM[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> PPAR Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease
Target	PPARγ:2 μM (EC50) PPARδ Human Endogenous Metabolite
In Vitro	15-Deoxy-Δ12,14-PGJ2 (15d-PGJ2) is a cyclopentenone prostaglandin that features an electrophilic, α, β-unsaturated ketone (an enone) in the cyclopentenone ring. 15-Deoxy-Δ-12,14-prostaglandin J2 is one of the cyPGs whose functions in inflammation, cell proliferation, survival, and apoptosis have been documented. 15-Deoxy-Δ-12,14-prostaglandin J2 activates PPARδ in a dose-dependent manner. 15-Deoxy-Δ-12,14-prostaglandin J2 activates PPARδ’s transcriptional activity through formation of a covalent adduct between its endocyclic enone at C9 and Cys249 in the receptor’s ligand-binding domain[1].
References	[1]. Reddy AT, et al. Identification and Molecular Characterization of Peroxisome Proliferator-Activated Receptor δ as a Novel Target for Covalent Modification by 15-Deoxy-Δ12,14-prostaglandin J2. CS Chem Biol. 2018 Dec 21;13(12):3269-3278. [2]. Kliewer SA1, et al. A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation. Cell. 1995 Dec 1;83(5):813-9.

Density	1.1±0.1 g/cm3
Boiling Point	495.8±34.0 °C at 760 mmHg
Molecular Formula	C₂₀H₂₈O₃
Molecular Weight	316.435
Flash Point	267.8±22.2 °C
Exact Mass	316.203857
PSA	54.37000
LogP	5.10
Vapour Pressure	0.0±2.7 mmHg at 25°C
Index of Refraction	1.558

Symbol	GHS02, GHS07
Signal Word	Danger
Hazard Statements	H225-H319-H336
Supplemental HS	Repeated exposure may cause skin dryness or cracking.
Precautionary Statements	P210-P280-P304 + P340 + P312-P305 + P351 + P338-P337 + P313-P403 + P235
Personal Protective Equipment	Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US)
Hazard Codes	F: Flammable;Xi: Irritant;
Risk Phrases	R11
Safety Phrases	16-26-29-33-36/37/39
RIDADR	UN 1231

Precursor 9
869801-20-7 1253966-22-1 60410-16-4 660430-04-6
426226-00-8 676235-98-6 676236-01-4 869801-10-5
869801-19-4
DownStream 0

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