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51165-11-8

51165-11-8 structure
51165-11-8 structure
  • Name: substance P (3-11)
  • Chemical Name: L-Methionyl-L-leucylglycyl-L-phenylalanyl-L-phenylalanyl-L-glutaminyl-L-glutaminyl-L-prolyl-L-lysinamide
  • CAS Number: 51165-11-8
  • Molecular Formula: C52H79N13O11S
  • Molecular Weight: 1094.329
  • Catalog: Research Areas Neurological Disease
  • Create Date: 2021-09-11 17:43:42
  • Modify Date: 2024-01-02 06:29:29
  • Substance P (3-11) is a substance P (SP) fragment peptide that can cross the BBB. Substance P (3-11) has contracting activities on guinea pig ileum. Substance P (3-11) also promotes human monocyte chemotaxis [1][2][5].

Name L-Methionyl-L-leucylglycyl-L-phenylalanyl-L-phenylalanyl-L-glutaminyl-L-glutaminyl-L-prolyl-L-lysinamide
Synonyms L-Lysinamide, L-methionyl-L-leucylglycyl-L-phenylalanyl-L-phenylalanyl-L-glutaminyl-L-glutaminyl-L-prolyl-
L-Methionyl-L-leucylglycyl-L-phenylalanyl-L-phenylalanyl-L-glutaminyl-L-glutaminyl-L-prolyl-L-lysinamide
Description Substance P (3-11) is a substance P (SP) fragment peptide that can cross the BBB. Substance P (3-11) has contracting activities on guinea pig ileum. Substance P (3-11) also promotes human monocyte chemotaxis [1][2][5].
Related Catalog
In Vitro Substance P (3-11) 可渗透 BBMEC 单层,渗透速率为 1.92 x 105 cm/s[2] Substance P (3-11) 在改进的 Boyden 室试验中促进人单核细胞趋化性[3]
In Vivo Substance P (3-11) (30 nmol/kg,静脉输注) 增加大鼠血浆中组胺水平[4]
References

[1]. Yanaihara N, et al. Immunological aspects of secretin, substance P, and VIP. Gastroenterology. 1977 Apr;72(4 Pt.2):803-10.  

[2]. Chappa AK, et al. Characteristics of substance P transport across the blood-brain barrier. Pharm Res. 2006 Jun;23(6):1201-8.  

[3]. Ruff MR, et al. Substance P receptor-mediated chemotaxis of human monocytes. Peptides. 1985;6 Suppl 2:107-11.  

[4]. Sertl K, et al. Substance P: the relationship between receptor distribution in rat lung and the capacity of substance P to stimulate vascular permeability. Am Rev Respir Dis. 1988 Jul;138(1):151-9.  

[5]. Freed AL, et al. Investigation of substance P transport across the blood-brain barrier. Peptides. 2002 Jan;23(1):157-65.  

Density 1.3±0.1 g/cm3
Boiling Point 1537.9±65.0 °C at 760 mmHg
Molecular Formula C52H79N13O11S
Molecular Weight 1094.329
Flash Point 883.9±34.3 °C
Exact Mass 1093.574219
LogP 0.65
Vapour Pressure 0.0±0.3 mmHg at 25°C
Index of Refraction 1.583