2305052-86-0
2305052-86-0 structure
- Name: BPK-25
- Chemical Name: BPK-25
- CAS Number: 2305052-86-0
- Molecular Formula: C21H17ClN4O2
- Molecular Weight: 392.84
- Catalog: Research Areas Inflammation/Immunology
- Create Date: 2021-09-18 12:07:03
- Modify Date: 2024-01-11 17:00:32
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BPK-25, an active acrylamide, promotes degradation of nucleosome remodeling and deacetylation (NuRD) complex proteins by a post-translational mechanism involving covalent protein engagement. BPK-25 inhibits TMEM173 activation by the cyclic dinucleotide ligand cGAMP[1].
| Name | BPK-25 |
|---|
| Description | BPK-25, an active acrylamide, promotes degradation of nucleosome remodeling and deacetylation (NuRD) complex proteins by a post-translational mechanism involving covalent protein engagement. BPK-25 inhibits TMEM173 activation by the cyclic dinucleotide ligand cGAMP[1]. |
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| Related Catalog | |
| In Vitro | BPK-21 (10 μM; 5 hours) inhibits TMEM173 activation by the cyclic dinucleotide ligand cGAMP[1]. BPK-25 (10 μM; 24 hours) suppresses NF-κB activation blocks nuclear factor of activated T-cells (NFAT) activation, as measured by >50% reductions in IκBα phosphorylation[1]. BPK-25 (10 μM; 4 hours) also reduced NFATc2 expression in T cells[1]. BPK-25 (0.1, 1, 5, 10, 20 μM; 24 hours) promotes the striking and selective reduction of several proteins in the nucleosome remodeling and deacetylation (NuRD) complex in a concentration- and time-dependent manner. BPK-25 does not have corresponding changes in mRNA expression[1]. A non-electrophilic propanamide analog of BPK-25 (BPK-25-ctrl) did not suppress T cell activation or affect NuRD complex proteins in T cells[1]. |
| References |
| Molecular Formula | C21H17ClN4O2 |
|---|---|
| Molecular Weight | 392.84 |