2305052-77-9

2305052-77-9 structure
2305052-77-9 structure
  • Name: BPK-21
  • Chemical Name: BPK-21
  • CAS Number: 2305052-77-9
  • Molecular Formula: C23H16Cl2F3NO2
  • Molecular Weight: 466.28
  • Catalog: Research Areas Inflammation/Immunology
  • Create Date: 2021-09-27 22:01:41
  • Modify Date: 2024-01-09 18:28:36
  • BPK-21, an active acrylamide, suppresses T cell activation through blockade of ERCC3 function. BPK-21 specifically targets C342 in the helicase ERCC3[1].

Name BPK-21
Description BPK-21, an active acrylamide, suppresses T cell activation through blockade of ERCC3 function. BPK-21 specifically targets C342 in the helicase ERCC3[1].
Related Catalog
In Vitro BPK-21 (20 μM) significantly impaired T cellactivation[1]. BPK-21 likely suppresses T cell activation through blockadeof ERCC3 function, which may in turn act downstream or sepa-rately from pathways involved in NFAT and NF-kB activation[1].
References

[1]. Ekaterina V Vinogradova, et al. An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29.

Molecular Formula C23H16Cl2F3NO2
Molecular Weight 466.28