1403933-79-8
1403933-79-8 structure
- Name: PP2A Cancerous-IN-1
- Chemical Name: PP2A Cancerous-IN-1
- CAS Number: 1403933-79-8
- Molecular Formula: C30H24N4O3
- Molecular Weight: 488.54
- Catalog: Signaling Pathways PI3K/Akt/mTOR Akt
- Create Date: 2021-09-05 19:32:50
- Modify Date: 2024-01-20 10:33:36
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PP2A Cancerous-IN-1 is a strong and potent CIP2A (Cancerous inhibitor of PP2A) and p-Akt inhibitor. PP2A Cancerous-IN-1 shows the most potent antiproliferative activities[1].
| Name | PP2A Cancerous-IN-1 |
|---|
| Description | PP2A Cancerous-IN-1 is a strong and potent CIP2A (Cancerous inhibitor of PP2A) and p-Akt inhibitor. PP2A Cancerous-IN-1 shows the most potent antiproliferative activities[1]. |
|---|---|
| Related Catalog | |
| Target |
pAKT |
| In Vitro | PP2A Cancerous-IN-1 (2.5 and 5 μM; 24 hours; SK-Hep-1 cells) reduces CIP2A expression and cell viability with a dose dependent manner and is more potent in its action than erlotinib[1]. PP2A Cancerous-IN-1 (5 μM; 24 hours; SK-Hep-1 cells) induces cell apoptosis[1]. PP2A Cancerous-IN-1 shows CIP2A inhibitory activity, reduces p-Akt level, induces PARP cleavage. PP2A Cancerous-IN-1 exhibits high potency with low IC50 values of 2.8 μM against HCC cells[1]. Cell Viability Assay[1] Cell Line: SK-Hep-1 cells Concentration: 2.5 and 5 μM Incubation Time: 24 hours Result: Reduced cell viability with a dose dependent manner. Western Blot Analysis[1] Cell Line: SK-Hep-1 cells Concentration: 2.5 and 5 μM Incubation Time: 24 hours Result: Reduced CIP2A expression. Apoptosis Analysis[1] Cell Line: SK-Hep-1 cells Concentration: 2.5 and 5 μM Incubation Time: 24 hours Result: Induced cell apoptosis. |
| References |
| Molecular Formula | C30H24N4O3 |
|---|---|
| Molecular Weight | 488.54 |