72983-78-9
72983-78-9 structure
- Name: 5-Iminodaunorubicin
- Chemical Name: 5-Iminodaunorubicin
- CAS Number: 72983-78-9
- Molecular Formula: C27H30N2O9
- Molecular Weight: 526.54
- Catalog: Signaling Pathways Cell Cycle/DNA Damage DNA/RNA Synthesis
- Create Date: 2021-10-26 20:18:59
- Modify Date: 2024-01-11 05:10:07
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5-Iminodaunorubicin is a quinone-modified anthracycline that retains antitumor activity[1]. 5-Iminodaunorubicin produces protein-concealed DNA strand breaks in cancer cells[2].
| Name | 5-Iminodaunorubicin |
|---|
| Description | 5-Iminodaunorubicin is a quinone-modified anthracycline that retains antitumor activity[1]. 5-Iminodaunorubicin produces protein-concealed DNA strand breaks in cancer cells[2]. |
|---|---|
| Related Catalog | |
| In Vitro | In mouse leukemia L1210 cells, 5-Iminodaunorubicin produces protein-concealed DNA strand breaks. Many of the 5-iminodaunorubicin breaks may arise from apposed single-strand breaks (i.e., double-strand breaks)[2]. |
| In Vivo | In rat, 5-Iminodaunorubicin (5-ID; 1-16 mg/kg) treatment produces widening of the QRS complex, increased R- and S-wave voltage, and prolonged the Q alpha T interval. And the quinone redox cycling is suppressed in 5-Iminodaunorubicin. 5-Iminodaunorubicin shows lower cardiotoxic[1]. |
| References |
| Molecular Formula | C27H30N2O9 |
|---|---|
| Molecular Weight | 526.54 |