Shanghai Nianxing Industrial Co., Ltd
China
Product Name: CP-601927
Price:
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang

DC Chemicals Limited
China
Product Name: CP-601927
Price: ￥Inquiry/100mg ￥Inquiry/250mg ￥Inquiry/1g
Purity: 98.0%
Stocking Period: 1 Day
Contact: Tony Cao

357425-02-6

357425-02-6 structure

357425-02-6 structure

Name: CP-601927
Chemical Name: CP-601927
CAS Number: 357425-02-6
Molecular Formula: C₁₂H₁₂F₃N
Molecular Weight: 227.23
Catalog: Signaling Pathways Membrane Transporter/Ion Channel nAChR
Create Date: 2021-10-12 10:14:47
Modify Date: 2024-01-14 13:45:22
CP-601927 is a selective α4β2 nicotinic acetylcholine receptor (nAChR) partial agonist (Ki=1.2 nM; EC50=2.6 μM). CP-601927 shows good brain penetration and antidepressant-like properties[1][2].

Name	CP-601927

Description	CP-601927 is a selective α4β2 nicotinic acetylcholine receptor (nAChR) partial agonist (Ki=1.2 nM; EC50=2.6 μM). CP-601927 shows good brain penetration and antidepressant-like properties[1][2].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR Signaling Pathways >> Neuronal Signaling >> nAChR Research Areas >> Neurological Disease
In Vivo	CP-601927 (0.125 mg/kg-1.5 mg/kg; i.p.; C57BL/6J male mice) has antidepressant-like activity in animal models[2].
References	[1]. Campion SN, et al. Toxicity study in juvenile rats with the α4β2 nicotinic acetylcholine receptor partial agonist CP-601,927. Birth Defects Res B Dev Reprod Toxicol. 2011;92(4):323-332. [2]. Mineur YS, et al. α4β2 nicotinic acetylcholine receptor partial agonists with low intrinsic efficacy have antidepressant-like properties. Behav Pharmacol. 2011;22(4):291-299.

Molecular Formula	C₁₂H₁₂F₃N
Molecular Weight	227.23