1794811-52-1

1794811-52-1 structure

1794811-52-1 structure

Name: Moxonidine-d4
Chemical Name: Moxonidine-d4
CAS Number: 1794811-52-1
Molecular Formula: C₉H₈D₄ClN₅O
Molecular Weight: 245.70
Catalog: Signaling Pathways GPCR/G Protein Imidazoline Receptor
Create Date: 2021-10-23 17:56:12
Modify Date: 2024-01-31 08:34:25
Moxonidine-d4 (BDF5895-d4) is the deuterium labeled Moxonidine. Moxonidine(BDF5895) is a selective agonist at the imidazoline receptor subtype 1, used as antihypertensive agent[1][2].

Name	Moxonidine-d4

Description	Moxonidine-d4 (BDF5895-d4) is the deuterium labeled Moxonidine. Moxonidine(BDF5895) is a selective agonist at the imidazoline receptor subtype 1, used as antihypertensive agent[1][2].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Imidazoline Receptor Signaling Pathways >> GPCR/G Protein >> Imidazoline Receptor Research Areas >> Neurological Disease
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Schafer, U., et al., Presynaptic effects of moxonidine in isolated buffer perfused rat hearts: role of imidazoline-1 receptors and alpha2-adrenoceptors. J Pharmacol Exp Ther, 2002. 303(3): p. 1163-70. [3]. Chan, C.K., et al., Imidazoline receptors associated with noradrenergic terminals in the rostral ventrolateral medulla mediate the hypotensive responses of moxonidine but not clonidine. Neuroscience, 2005. 132(4): p. 991-1007.

Molecular Formula	C₉H₈D₄ClN₅O
Molecular Weight	245.70