Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Pyrimethamine-d3
Price:
Purity: 98.0%
Stocking Period: 10 Day
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1189936-99-9

1189936-99-9 structure

Name: Pyrimethamine-d3
Chemical Name: Pyrimethamine-d3
CAS Number: 1189936-99-9
Molecular Formula: C₁₂H₁₀D₃ClN₄
Molecular Weight: 251.73
Catalog: Signaling Pathways Cell Cycle/DNA Damage Antifolate
Create Date: 2021-10-11 17:10:38
Modify Date: 2024-01-09 14:13:47
Pyrimethamine-d3 (Pirimecidan-d3) is the deuterium labeled Pyrimethamine. Pyrimethamine is a medication used for protozoal infections; interferes with tetrahydrofolic acid synthesis from folic acid by inhibiting the enzyme dihydrofolate reductase (DHFR)[1][2].

Name	Pyrimethamine-d3

Description	Pyrimethamine-d3 (Pirimecidan-d3) is the deuterium labeled Pyrimethamine. Pyrimethamine is a medication used for protozoal infections; interferes with tetrahydrofolic acid synthesis from folic acid by inhibiting the enzyme dihydrofolate reductase (DHFR)[1][2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Cell Cycle/DNA Damage >> Antifolate
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Basco LK, et al. In vitro activity of pyrimethamine, cycloguanil, and other antimalarial drugs against African isolates and clones of Plasmodium falciparum. Am J Trop Med Hyg. 1994 Feb; 50(2):193-9. [3]. Inceboz T, et al. Preparation of (131)I-Pyrimethamine and evaluation for scintigraphy of experimentally Toxoplasma gondii-infectedrats. J Drug Target. 2013 Feb;21(2):175-9. [4]. Wright PD, et al. Screening for inhibitors of the SOD1 gene promoter: pyrimethamine does not reduce SOD1 levels in cell and animal models. Neurosci Lett. 2010 Oct 4;482(3):188-92. [5]. Martins-Duarte ES, et al. Toxoplasma gondii: the effect of fluconazole combined with sulfadiazine and pyrimethamine against acute toxoplasmosis in murine model. Exp Parasitol. 2013 Mar;133(3):294-9. [6]. Taylor WR, et al. Antimalarial drug toxicity: a review. Drug Saf. 2004;27(1):25-61.

Molecular Formula	C₁₂H₁₀D₃ClN₄
Molecular Weight	251.73

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