Shanghai Nianxing Industrial Co., Ltd
China
Product Name: sulfo-DGN462 sodium
Price:
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang

1401203-09-5

1401203-09-5 structure

1401203-09-5 structure

Name: sulfo-DGN462 sodium
Chemical Name: sulfo-DGN462 sodium
CAS Number: 1401203-09-5
Molecular Formula: C₅₃H₆₀N₅NaO₁₂S₂
Molecular Weight: 1046.19
Catalog: Signaling Pathways Antibody-drug Conjugate ADC Cytotoxin
Create Date: 2021-10-23 08:09:46
Modify Date: 2024-01-12 13:13:35
sulfo-DGN462 sodium is degraded to DGN462 in culture medium and plasma. DGN462, a potent DNA-alkylating agent, shows anti-tumor activity, such as acute myeloid leukemia (AML)[1].

Name	sulfo-DGN462 sodium

Description	sulfo-DGN462 sodium is degraded to DGN462 in culture medium and plasma. DGN462, a potent DNA-alkylating agent, shows anti-tumor activity, such as acute myeloid leukemia (AML)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Cytotoxin Signaling Pathways >> Cell Cycle/DNA Damage >> DNA Alkylator/Crosslinker
In Vitro	DGN462 can be used as a cytotoxic component of antibody-drug conjugates (ADCs). DGN462 is a member of the DNA-alkylating indolinobenzodiazepine pseudodimers (IGNs) class[1].
References	[1]. Hicks SW, et al. The novel CD19-targeting antibody-drug conjugate huB4-DGN462 shows improved anti-tumor activity compared to SAR3419 in CD19-positive lymphoma and leukemia models. Haematologica. 2019 Aug;104(8):1633-1639.

Molecular Formula	C₅₃H₆₀N₅NaO₁₂S₂
Molecular Weight	1046.19