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Product Name: nisin Z
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137061-46-2

137061-46-2 structure

137061-46-2 structure

Name: nisin Z
Chemical Name: nisin Z
CAS Number: 137061-46-2
Molecular Formula: C₁₄₁H₂₂₉N₄₁O₃₈S₇
Molecular Weight: 3331.03
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2021-11-21 20:18:58
Modify Date: 2024-01-03 10:17:10
Nisin Z is an antimicrobial and anti-inflammatory peptide. Nisin Z is effective against Gram-positive bacteria and fungi, such as C. albicans[1][4].

Name	nisin Z
Synonyms	MFCD00131724 EINECS 215-807-5

Description	Nisin Z is an antimicrobial and anti-inflammatory peptide. Nisin Z is effective against Gram-positive bacteria and fungi, such as C. albicans[1][4].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Fungal Research Areas >> Inflammation/Immunology Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	Nisin Z (10 μg/mL, 24 h) 增加牙龈成纤维细胞的脱离和分化[2]。 Nisin Z (25-75 μg/mL，24 小时) 抑制 C. albicans 粘附于牙龈细胞[2]. Nisin Z (500 和 1000 μg/mL，24 小时) 抑制 C. albicans 胚芽管形成[3]. Nisin Z (100 μg/mL，12 小时) 减少 MCF10A 细胞中 LPS 诱导的促炎细胞因子 (即 IL-6、TNF-α、IL-1β) 的产生[4] . Nisin Z (10-100 μg/mL, 12 h) 抑制 LPS 诱导的 MCF10A 细胞中 ERK1/2 和 p38 MAPK 信号通路的激活[4]。 Cell Viability Assay[3] Cell Line: C. albicans Concentration: 100, 500, 1000 μg/mL Incubation Time: 24, 48, and 72 h Result: Reduced C. albicans growth. Western Blot Analysis[4] Cell Line: LPS-induced MCF10A cells Concentration: 10-100 μg/mL Incubation Time: 12 h Result: Inhibited the phosphorylation of p38 and and ERK1/2.
In Vivo	Nisin Z (1、5 和 10 mg/kg，i.p.) 可预防 LPS 引起的小鼠乳腺炎模型中的病理损伤[4]。 Animal Model: Mastitis mouse model[4] Dosage: 1, 5, and 10 mg/kg Administration: i.p., one hour before treatment of LPS. Result: Reduced inflammatory cell infiltration. Showed a reduction in inflammatory cytokine levels.
References	[1]. Webber JL, et al. Incorporation and antimicrobial activity of nisin Z within carrageenan/chitosan multilayers. Sci Rep. 2021 Jan 18;11(1):1690. [2]. Akerey B, et al. In vitro efficacy of nisin Z against Candida albicans adhesion and transition following contact with normal human gingival cells. J Appl Microbiol. 2009 Oct;107(4):1298-307. [3]. Le Lay C, et al. Nisin Z inhibits the growth of Candida albicans and its transition from blastospore to hyphal form. J Appl Microbiol. 2008 Nov;105(5):1630-9. [4]. Huang F, et al. Nisin Z attenuates lipopolysaccharide-induced mastitis by inhibiting the ERK1/2 and p38 mitogen-activated protein kinase signaling pathways. J Dairy Sci. 2022 Apr;105(4):3530-3543.

Density	1.40±0.1 g/cm3(Predicted)
Boiling Point	2962.5±65.0 °C(Predicted)
Molecular Formula	C₁₄₁H₂₂₉N₄₁O₃₈S₇
Molecular Weight	3331.03
Storage condition	2-8℃

Hazard Codes	Xn
Risk Phrases	22-36/37/38
Safety Phrases	22-24/25-36-26