1403894-72-3

1403894-72-3 structure

Name: Mesdopetam
Chemical Name: N-{2-[3-Fluoro-5-(methylsulfonyl)phenoxy]ethyl}-1-propanamine
CAS Number: 1403894-72-3
Molecular Formula: C₁₂H₁₈FNO₃S
Molecular Weight: 275.34
Catalog: Signaling Pathways GPCR/G Protein Dopamine Receptor
Create Date: 2021-12-20 17:32:48
Modify Date: 2024-01-02 17:26:25
Mesdopetam (IRL790) is a dopamine D3 receptor antagonist (Ki=90 nM; IC50=9.8 μM for human recombinant D3 receptor) with psychomotor stabilizing properties. Mesdopetam is used for the research of motor and psychiatric complications in Parkinson disease[1][2].

Name	N-{2-[3-Fluoro-5-(methylsulfonyl)phenoxy]ethyl}-1-propanamine
Synonyms	1-Propanamine, N-[2-[3-fluoro-5-(methylsulfonyl)phenoxy]ethyl]- N-{2-[3-Fluoro-5-(methylsulfonyl)phenoxy]ethyl}-1-propanamine

Description	Mesdopetam (IRL790) is a dopamine D3 receptor antagonist (Ki=90 nM; IC50=9.8 μM for human recombinant D3 receptor) with psychomotor stabilizing properties. Mesdopetam is used for the research of motor and psychiatric complications in Parkinson disease[1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease
Target	D3 Receptor
In Vivo	Mesdopetam (IRL790) (3.7, 11, 33, or 100 µmol/kg) dose-dependently inhibits the behavioral activation following pretreatment with D-amphetamine or MK-80[1]. Mesdopetam (10 mg/kg; intraperitoneally; fourteen-week-old male C57BL/J mice) promotes a sedative effect similar to haloperidol with significantly reduced total distance traveled and reduced average speed[2]. Animal Model: Male Sprague-Dawley rats[1] Dosage: 3.7, 11, 33, or 100 µmol/kg (synthesized in-house as HCl salt, was dissolved in physiologic saline (0.9% w/v NaCl) Administration: s.c. was administered subcutaneously 4 min before the start of recording Result: Dose-dependently inhibited the behavioral activation following pretreatment with D-amphetamine or MK-801.
References	[1]. Waters S, et al. Preclinical Pharmacology of [2-(3-Fluoro-5-Methanesulfonyl-phenoxy)Ethyl](Propyl)amine (IRL790), a Novel Dopamine Transmission Modulator for the Treatment of Motor and Psychiatric Complications in Parkinson Disease. J Pharmacol Exp Ther. 2020;374(1):113-125. [2]. Becanovic K, et al. Effects of a Novel Psychomotor Stabilizer, IRL790, on Biochemical Measures of Synaptic Markers and Neurotransmission. J Pharmacol Exp Ther. 2020;374(1):126-133.

Density	1.2±0.1 g/cm3
Boiling Point	428.5±45.0 °C at 760 mmHg
Molecular Formula	C₁₂H₁₈FNO₃S
Molecular Weight	275.34
Flash Point	212.9±28.7 °C
Exact Mass	275.099152
LogP	1.50
Vapour Pressure	0.0±1.0 mmHg at 25°C
Index of Refraction	1.500

1403894-72-3	2562346-14-7
1342881-20-2	1158522-08-7
940364-43-2	737766-42-6
134104-43-1	1353519-29-5
131615-57-1	6906-52-1
930439-75-1	1018584-77-4