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2687273-52-3

2687273-52-3 structure
2687273-52-3 structure
  • Name: PARP/EZH2-IN-1
  • Chemical Name: PARP/EZH2-IN-1
  • CAS Number: 2687273-52-3
  • Molecular Formula: C43H41FN8O5
  • Molecular Weight: 768.83
  • Catalog: Signaling Pathways Cell Cycle/DNA Damage PARP
  • Create Date: 2021-12-19 11:33:30
  • Modify Date: 2024-01-24 08:36:27
  • PARP/EZH2-IN-1 is a first-in-class dual PARP (IC50 6.87 nM) and EZH2 (IC50 36.51 nM) inhibitor for triple-negative breast cancer with wild-type BRCA.

Name PARP/EZH2-IN-1
Description PARP/EZH2-IN-1 is a first-in-class dual PARP (IC50 6.87 nM) and EZH2 (IC50 36.51 nM) inhibitor for triple-negative breast cancer with wild-type BRCA.
Related Catalog
Target

PARP-1:6.87 nM (IC50)

EZH2:36.51 nM (IC50)

References

[1]. Wang C, et al. Discovery of First-in-Class Dual PARP and EZH2 Inhibitors for Triple-Negative Breast Cancer with Wild-Type BRCA. J Med Chem. 2021 Sep 9;64(17):12630-12650.

Molecular Formula C43H41FN8O5
Molecular Weight 768.83