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2480226-07-9

2480226-07-9 structure
2480226-07-9 structure
  • Name: Simufilam hydrochloride
  • Chemical Name: Simufilam hydrochloride
  • CAS Number: 2480226-07-9
  • Molecular Formula: C15H22ClN3O
  • Molecular Weight: 295.81
  • Catalog: Research Areas Neurological Disease
  • Create Date: 2022-02-25 16:21:27
  • Modify Date: 2024-01-24 20:14:11
  • Simufilam (PTI-125) (hydrochloride) is a low toxicity, orally active filamin A (FLNA) activator. Simufilam (hydrochloride) preferentially binds altered FLNA and restores its native conformation, restores receptor and synaptic activities, reduces its a7nAChR/TLR4 associations and downstream pathologies. Simufilam (hydrochloride) can be used for the research of Alzheimer's disease[1].
Name Simufilam hydrochloride
Description Simufilam (PTI-125) (hydrochloride) is a low toxicity, orally active filamin A (FLNA) activator. Simufilam (hydrochloride) preferentially binds altered FLNA and restores its native conformation, restores receptor and synaptic activities, reduces its a7nAChR/TLR4 associations and downstream pathologies. Simufilam (hydrochloride) can be used for the research of Alzheimer's disease[1].
Related Catalog
Target

FLNA[1]

In Vitro Simufilam (1 pM~1 nM) (hydrochloride) dose-dependently improves NMDA/glycine-induced Arc expression[1]. Simufilam (1 nM, 1 hour) (hydrochloride) largely restores filamin A to its native conformation and is effective in normalizing receptor activities in AD frontal cortices. Simufilam (hydrochloride) dose-dependently reduces Ab42-induced FLNA coupling to a7nAChR and TLR4 in both Ab42-treated control and AD hippocampus. Simufilam (hydrochloride) reduces Ab42's binding affinity for a7nAChR, thereby prevents Ab42's signaling and further accumulation on a7nAChRs[1].
In Vivo Simufilam (P.o.; 2 months) (hydrochloride) restores FLNA to its native conformation. Simufilam (22 mg/kg; p.o.) (hydrochloride) robustly reduces FLNAea7nAChR/TLR4 associations. Simufilam (hydrochloride) significantly improves spatial memory. Simufilam (hydrochloride) significantly improves working memory[1].
References

[1]. Wang HY, et al. PTI-125 binds and reverses an altered conformation of filamin A to reduce Alzheimer's disease pathogenesis. Neurobiol Aging. 2017;55:99-114.
Molecular Formula C15H22ClN3O
Molecular Weight 295.81

Chemsrc provides CAS#:2480226-07-9 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 2480226-07-9 | Chemsrc address: https://www.chemsrc.com/en/baike/1687352.html

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