2230956-57-5

2230956-57-5 structure

Name: Thalidomide-5-PEG2-Cl
Chemical Name: Thalidomide-5-PEG2-Cl
CAS Number: 2230956-57-5
Molecular Formula: C₁₇H₁₇ClN₂O₆
Molecular Weight: 380.78
Catalog: Signaling Pathways PROTAC Ligand for E3 Ligase
Create Date: 2021-12-19 17:15:00
Modify Date: 2024-01-09 11:09:50
Thalidomide-5-PEG2-Cl is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5-PEG2-Cl can be connected to the ligand for protein by a linker to form PROTACs[1].

Name	Thalidomide-5-PEG2-Cl

Description	Thalidomide-5-PEG2-Cl is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5-PEG2-Cl can be connected to the ligand for protein by a linker to form PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> Ligand for E3 Ligase
Target	Cereblon
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-994.