675848-25-6

675848-25-6 structure

Name: VO-OHpic
Chemical Name: VO-OHpic
CAS Number: 675848-25-6
Molecular Formula: C₁₂H₁₀N₂O₈V
Molecular Weight: 361.16
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2022-03-13 17:29:55
Modify Date: 2024-01-14 08:51:49
VO-OHPic is a reversible, noncompetitive and selective PTEN inhibitor with an IC50 of 46 nM. VO-OHPic attenuates apoptosis, adverse cardiac remodeling, and pro-inflammatory M1 macrophages in doxorubicin-induced cardiomyopathy. VO-OHPic inhibits autophagy[1][2][3].

Name	VO-OHpic
Synonyms	(OC-6-45)-Aqua(3-hydroxy-2-pyridinecarboxylato-κ-N1,κO2)[3-(hydroxy-κO)-2-pyridinecarboxylato(2-)-κO2]oxovanadate(1-),hydrogen

Description	VO-OHPic is a reversible, noncompetitive and selective PTEN inhibitor with an IC50 of 46 nM. VO-OHPic attenuates apoptosis, adverse cardiac remodeling, and pro-inflammatory M1 macrophages in doxorubicin-induced cardiomyopathy. VO-OHPic inhibits autophagy[1][2][3].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Research Areas >> Cardiovascular Disease Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> PI3K/Akt/mTOR >> PTEN Research Areas >> Inflammation/Immunology Research Areas >> Metabolic Disease
Target	IC50: 46 nM (PTEN)[1]
References	[1]. Mak LH, et al. Characterisation of the PTEN inhibitor VO-OHpic. J Chem Biol. 2010 Oct;3(4):157-63. doi: 10.1007/s12154-010-0041-7. Epub 2010 Jun 4. [2]. Johnson TA, et al. PTEN inhibitor VO-OHpic attenuates inflammatory M1 macrophages and cardiac remodeling in doxorubicin-induced cardiomyopathy. Am J Physiol Heart Circ Physiol. 2018 Nov 1;315(5):H1236-H1249. [3]. Wang W, et al. PTEN inhibitor VO-OHpic suppresses TSC2-/- MEFs proliferation by excessively inhibiting autophagy via the PTEN/PRAS40 pathway. Exp Ther Med. 2020 Jun;19(6):3565-3570.

Molecular Formula	C₁₂H₁₀N₂O₈V
Molecular Weight	361.16