4445-03-8

4445-03-8 structure

4445-03-8 structure

Name: HO-PEG18-OH
Chemical Name: HO-PEG18-OH
CAS Number: 4445-03-8
Molecular Formula: C₃₆H₇₄O₁₉
Molecular Weight: 810.96
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2022-04-02 13:08:19
Modify Date: 2024-04-07 15:29:36
HO-PEG18-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	HO-PEG18-OH

Description	HO-PEG18-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

Molecular Formula	C₃₆H₇₄O₁₉
Molecular Weight	810.96