1020567-30-9

1020567-30-9 structure

Name: GSK2324
Chemical Name: GSK-2324
CAS Number: 1020567-30-9
Molecular Formula: C₂₉H₂₂Cl₂N₂O₄
Molecular Weight: 533.40200
Catalog: Signaling Pathways Metabolic Enzyme/Protease FXR
Create Date: 2022-07-01 00:36:05
Modify Date: 2024-01-05 21:11:39
GSK2324 (Compd 1c) is a FXR agonist for diabetes study, with an EC50 of 120 nM. GSK2324 exhibits t1/2 values of 84 min (mouse), 170 min (rat), 110 min (beagle) and 120 min (cyno), respectively[1].

Name	GSK-2324
Synonyms	6-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-2-quinolinecarboxylic acid

Description	GSK2324 (Compd 1c) is a FXR agonist for diabetes study, with an EC50 of 120 nM. GSK2324 exhibits t1/2 values of 84 min (mouse), 170 min (rat), 110 min (beagle) and 120 min (cyno), respectively[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> FXR Research Areas >> Metabolic Disease
References	[1]. Jonathan Y Bass, et al. Conformationally constrained farnesoid X receptor (FXR) agonists: heteroaryl replacements of the naphthalene. Bioorg Med Chem Lett. 2011 Feb 15;21(4):1206-13.