1802703-20-3
1802703-20-3 structure
- Name: AAK1-IN-3
- Chemical Name: AAK1-IN-3
- CAS Number: 1802703-20-3
- Molecular Formula: C20H20N4
- Molecular Weight: 316.40
- Catalog: Research Areas Neurological Disease
- Create Date: 2022-05-25 11:28:52
- Modify Date: 2024-01-08 02:17:42
-
AAK1-IN-3, a quinoline analogue, is a brain-penetrant adaptor protein 2-associated kinase 1 (AAK1) inhibitor with an IC50 of 11 nM. AAK1-IN-3 has the potential for neuropathic pain research[1].
| Name | AAK1-IN-3 |
|---|
| Description | AAK1-IN-3, a quinoline analogue, is a brain-penetrant adaptor protein 2-associated kinase 1 (AAK1) inhibitor with an IC50 of 11 nM. AAK1-IN-3 has the potential for neuropathic pain research[1]. |
|---|---|
| Related Catalog | |
| In Vitro | AAK1-IN-3 (compound (R)-31) is brain-penetrant kinase inhibitors with a B/P ratio of 1.3[1]. AAK1-IN-3 inhibits AAK1 in HEK293 cells (IC50=108 nM)[1]. |
| In Vivo | AAK1-IN-3 (compound (R)-31; 30 mg/kg; sc; signle dose) causes a 46% reduction of μ2 phosphorylation in C57BL6 mice[1]. |
| References |
| Molecular Formula | C20H20N4 |
|---|---|
| Molecular Weight | 316.40 |