1815613-44-5
1815613-44-5 structure
- Name: AAK1-IN-5
- Chemical Name: AAK1-IN-5
- CAS Number: 1815613-44-5
- Molecular Formula: C19H23F4N3O
- Molecular Weight: 385.40
- Create Date: 2022-05-24 23:56:52
- Modify Date: 2024-01-10 09:23:31
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AAK1-IN-5 is a highly selective, CNS-penetrable, and orally active adaptor protein-2-associated kinase 1 (AAK1) inhibitor (AAK1 IC50 of 1.2 nM, Filt Ki of 0.05 nM, and cell IC50 of 0.5 nM). AAK1-IN-4 has the potential for the research for neuropathic pain[1].
| Name | AAK1-IN-5 |
|---|
| Description | AAK1-IN-5 is a highly selective, CNS-penetrable, and orally active adaptor protein-2-associated kinase 1 (AAK1) inhibitor (AAK1 IC50 of 1.2 nM, Filt Ki of 0.05 nM, and cell IC50 of 0.5 nM). AAK1-IN-4 has the potential for the research for neuropathic pain[1]. |
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| Related Catalog | |
| Target |
IC50: 1.2 nM (AAK1)[1]. Ki: 0.05 nM (AAK1)[1] |
| In Vitro | AAK1-IN-5 (compound 58) (0.5 μM, 0-10 min) has a good metabolic stability, with half-life values of over 120 min in human and mouse liver microsomes, and 76.0, 17.6, 26.0 min in rat, cynomolgus monkey, and dog, respectively[1]. |
| In Vivo | AAK1-IN-5 (compound 58) can reduce hyperalgesia in SD rats (chronic constriction injury) efficiently with good efficacy observed at doses of 1 and 3 mg/kg[1]. Animal Model: Male Sprague-Dawley rats (chronic constriction injury, CCI)[1] Dosage: 1-3 mg/kg Administration: p.o., 0-5.5 hours Result: Reduced hyperalgesia in CCI rats efficiently with good efficacy observed at doses of 1 and 3 mg/kg. |
| References |
| Molecular Formula | C19H23F4N3O |
|---|---|
| Molecular Weight | 385.40 |