AAK1-IN-5

Modify Date: 2024-01-10 09:23:31

AAK1-IN-5 structure	Common Name	AAK1-IN-5
	CAS Number	1815613-44-5	Molecular Weight	385.40
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₉H₂₃F₄N₃O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of AAK1-IN-5

AAK1-IN-5 is a highly selective, CNS-penetrable, and orally active adaptor protein-2-associated kinase 1 (AAK1) inhibitor (AAK1 IC50 of 1.2 nM, Filt Ki of 0.05 nM, and cell IC50 of 0.5 nM). AAK1-IN-4 has the potential for the research for neuropathic pain[1].

Name	AAK1-IN-5

Description	AAK1-IN-5 is a highly selective, CNS-penetrable, and orally active adaptor protein-2-associated kinase 1 (AAK1) inhibitor (AAK1 IC50 of 1.2 nM, Filt Ki of 0.05 nM, and cell IC50 of 0.5 nM). AAK1-IN-4 has the potential for the research for neuropathic pain[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
Target	IC50: 1.2 nM (AAK1)[1]. Ki: 0.05 nM (AAK1)[1]
In Vitro	AAK1-IN-5 (compound 58) (0.5 μM, 0-10 min) has a good metabolic stability, with half-life values of over 120 min in human and mouse liver microsomes, and 76.0, 17.6, 26.0 min in rat, cynomolgus monkey, and dog, respectively[1].
In Vivo	AAK1-IN-5 (compound 58) can reduce hyperalgesia in SD rats (chronic constriction injury) efficiently with good efficacy observed at doses of 1 and 3 mg/kg[1]. Animal Model: Male Sprague-Dawley rats (chronic constriction injury, CCI)[1] Dosage: 1-3 mg/kg Administration: p.o., 0-5.5 hours Result: Reduced hyperalgesia in CCI rats efficiently with good efficacy observed at doses of 1 and 3 mg/kg.
References	[1]. Luo G, et al. Discovery and Optimization of Biaryl Alkyl Ethers as a Novel Class of Highly Selective, CNS-Penetrable, and Orally Active Adaptor Protein-2-Associated Kinase 1 (AAK1) Inhibitors for the Potential Treatment of Neuropathic Pain. J Med Chem. 2022;65(6):4534-4564.

Molecular Formula	C₁₉H₂₃F₄N₃O
Molecular Weight	385.40

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: AAK1-IN-5
Price: ￥Inquiry/100mg ￥Inquiry/250mg ￥Inquiry/1g
Purity: 98.0%
Delivery: 10 Day
Contact: Huang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: AAK1-IN-5
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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