Nampt-IN-5
Modify Date: 2024-01-20 19:24:47
Nampt-IN-5 structure
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Common Name | Nampt-IN-5 | ||
|---|---|---|---|---|
| CAS Number | 2380013-17-0 | Molecular Weight | 427.50 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C25H25N5O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Nampt-IN-5Nampt-IN-5 is a potent and orally active nicotinamide phosphoribosyltransferase (NAMPT) inhibitor. Nampt-IN-5 inhibits CYP3A4 activity and has cellular IC50s of 0.7 nM and 3.9 nM against A2780 and COR-L23, respectively[1]. |
| Name | Nampt-IN-5 |
|---|
| Description | Nampt-IN-5 is a potent and orally active nicotinamide phosphoribosyltransferase (NAMPT) inhibitor. Nampt-IN-5 inhibits CYP3A4 activity and has cellular IC50s of 0.7 nM and 3.9 nM against A2780 and COR-L23, respectively[1]. |
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| Related Catalog | |
| Target |
IC50: Nampt[1] |
| In Vitro | Nampt-IN-5 (0-10 nM; 3 days) has cellular IC50s of 0.7 nM and 3.9 nM against A2780 and COR-L23, respectively in CellTiterGlo (CTG) assays[1]. Nampt-IN-5 shows a good ADME data: mouse microsomal clearance (110 μl/min*mg), CYP3A4 inhibition value (0.75 μM), Sol6.8: 0.056 mM; MDCK Papp AB: 18.6[1]. |
| References |
| Molecular Formula | C25H25N5O2 |
|---|---|
| Molecular Weight | 427.50 |
| Storage condition | 2-8°C |